Mucosal adaptation changes after urinary diversion. Saad Eissa NCI-Cairo University . intact junctional complexes. prominent filamentous core rootlets, with haphazard orientation. . Altered mitochondrial morphology with dilated cristae. increased amounts of intracellular vacuoles.
Solitary, apically located ribosomes were more abundant in ileal than in colonic mucosa
Some areas of colonic mucosa were denuded of microvilli and showed bleb formation.
Electron-dense particles, lipid depositions, situated in Golgi apparatus and lying free in the cytoplasm.
intact tight junctions which indicate that an important morphological requirement of maintained epithelial barrier function is present in mucosa deprived of normal luminal stimulation or after contact with urine.
Fortunately, the clinical significance of electrolyte abnormalities resulting from urinary diversion through ileal or colonic segments, at least in the short term, appears to be minimal in the patient with normal renal function.