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Sex, Stress, and Oxygen Deprivation: Gender-Specific Phenotypes Modulate Survival in Anoxia . Michelle LeBlanc University of North Texas Ronald E. McNair Program. Oxygen Deprivation. What is Anoxia? <.001 kilopascal of oxygen in environment Health Issues Stroke Ischemia

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sex stress and oxygen deprivation gender specific phenotypes modulate survival in anoxia

Sex, Stress, and Oxygen Deprivation: Gender-Specific Phenotypes Modulate Survival in Anoxia 

Michelle LeBlanc

University of North Texas

Ronald E. McNair Program

oxygen deprivation
Oxygen Deprivation
  • What is Anoxia?
    • <.001 kilopascal of oxygen in environment
    • Health Issues
      • Stroke
      • Ischemia
      • Center of cancerous tumors
    • Environmental Deficits
      • Oceanic dead zones
suspended animation
Suspended Animation
  • Reversible state of dormancy
    • initiated due to environmental stress
  • Mammals
    • Hibernation
    • Estivation
  • We can study SA with the model organism Caenorhabditis elegans!!
caenorhabditis elegans
Caenorhabditis elegans

Image adapted from Wormbook

hypothesis
Hypothesis
  • An modification in gonad function will modulate survival of long-term oxygen deprivation.
    • Sterile animals may survive anoxia differently than wild-type animals.
    • Sex may modulate survival in anoxia.
future aims
Future Aims
  • What underlies the fog-2(q71) phenotype?
    • Sperm signaling
    • Signaling from fertilized embryo
  • Does oocyte flux affect survival?
    • spe-12(hc76) and fer-15(hc15)
      • Animals that cannot produce spermatids
acknowledgements
Acknowledgements

Dr. Pamela Padilla

Alexander Mendenhall and Desh Mohan, project collaborators

The rest of the Padilla lab

Ronald E. McNair Program

references
References
  • BOUTILIER, R. G., and J. ST-PIERRE, 2000 Surviving hypoxia without really dying. Comp Biochem Physiol A Mol Integr Physiol 126: 481-490.
  • BURGGREN, W., and A. MWALUKOMA, 1983 Respiration during chronic hypoxia and hyperoxia in larval and adult bullfrogs (Rana catesbeiana). I. Morphological responses of lungs, skin and gills. J Exp Biol 105: 191-203.
  • GEMS, D., and D. L. RIDDLE, 2000 Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154: 1597-1610.
  • HAJERI, V. A., J. TREJO and P. A. PADILLA, 2005 Characterization of sub-nuclear changes in Caenorhabditis elegans embryos exposed to brief, intermediate and long-term anoxia to analyze anoxia-induced cell cycle arrest. BMC Cell Biol 6:47.
  • KORNFELD, K., D. B. HOM and H. R. HORVITZ, 1995 The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83: 903-913.
  • NYSTUL, T. G., J. P. GOLDMARK, P. A. PADILLA and M. B. ROTH, 2003 Suspended animation in C. elegans requires the spindle checkpoint. Science 302: 1038-1041.