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Concentrations of Anti-RON ADCs ( μ g/ml)

Caption: Effect of Zt/g4-DM1 on reduction of cell viability in CRC cell lines expressing different numbers of RON receptor. LoVo: RON per cell <10. DLD1: RON per cell ~4,480. SW620: RON per cell ~11,256. HT29 : RON per cell ~18,797. 100. IC 50 ( μ g/ml) Zt/g4-DM1: >100

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Concentrations of Anti-RON ADCs ( μ g/ml)

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  1. Caption: Effect of Zt/g4-DM1 on reduction of cell viability in CRC cell lines expressing different numbers of RON receptor LoVo: RON per cell <10 DLD1: RON per cell ~4,480 SW620: RON per cell ~11,256 HT29: RON per cell ~18,797 100 IC50 (μg/ml) Zt/g4-DM1: >100 Zt/c1-DM1: >100 IC50 (μg/ml) Zt/g4-DM1: 1.65 Zt/c1-DM1: 6.24 IC50 (μg/ml) Zt/g4-DM1: 4.03 Zt/c1-DM1: 4.36 IC50 (μg/ml) Zt/g4-DM1: 20.36 Zt/c1-DM1: 21.14 Cell viability (% of control) 80 60 40 20 Concentrations of Anti-RON ADCs (μg/ml) 0 0 3 6 9 12 15 Feng et al. Supplementary Fig. 3

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