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Effects of Olmesartan Medoxomil and PD-123319 on BALF in Experimental Models

This study investigates the impact of olmesartan medoxomil and PD-123319 on bronchoalveolar lavage fluid (BALF) across different dosing regimens in two distinct experiments. In Experiment 1, varying concentrations of olmesartan (0.1 mg/kg and 1 mg/kg, administered orally) are evaluated alongside vehicle and saline controls on Day 0, Day 7, and Day 14. Experiment 2 examines the effects of PD-123319 (0.5 mg/kg and 5 mg/kg, subcutaneously) compared to saline control, focusing on their influence on BALF.

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Effects of Olmesartan Medoxomil and PD-123319 on BALF in Experimental Models

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  1. BALF BLM 2 mg/kg i.t. or Saline i.t. BALF or Sacrifice Day 0 Day 7 Day 14 Experiment 1 (Effects of olmesartan medoxomil) BLM + Vehicle Vehicle (p.o.) BLM + OL (0.1) olmesartan 0.1 mg/kg/day (p.o.) BLM + OL (1) olmesartan 1 mg/kg/day (p.o.) Saline + OL (1) olmesartan 1 mg/kg/day (p.o.) Saline + Vehicle Vehicle (p.o.) Experiment 2 (Effects of PD-123319) BLM + Saline Saline (s.c.) BLM + PD (0.5) PD-123319 0.5 mg/kg/day (s.c.) BLM + PD (5) PD-123319 5 mg/kg/day (s.c.) Saline + PD (5) PD-123319 5 mg/kg/day (s.c.) Saline + Saline Saline (s.c.)

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