1 / 15

Gastric Malignancies Explained: Adenocarcinoma, GIST, Lymphoma, Polyps

Understand the epidemiology, pathology, clinical presentation, diagnosis, and treatment of gastric malignancies including adenocarcinoma, GI stromal tumors (GIST), primary gastric lymphoma, and gastric polyps. Explore key factors contributing to the development of adenocarcinoma, its different classifications, stage grouping, and diagnostic methods.

tpugh
Download Presentation

Gastric Malignancies Explained: Adenocarcinoma, GIST, Lymphoma, Polyps

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. GASTRIC MALIGNANCIES Klara Matijević Mentor: A. Žmegač Horvat

  2. adenocarcinoma • gastrointestinal stromal tumours (GIST) • primary gastric lymphoma • gastric polyps

  3. ADENOCARCINOMA • 4th most common cancer world-wide • 2nd leading cause of cancer-related mortality • incidence increases with age (rare under the age of 30) • highest incidence: Eastern Asia (Japan), Eastern Europe, South America • men:women = 2:1

  4. Epidemiology • H.pylori infection (group 1 gastric carcinogen) • dietary factors • smoking tobacco • genetic abnormalities • increased risk after partial gastrectomy

  5. Diagram showing the development ofgastric cancer associated with H.pylori infection

  6. Pathology • Lauren classification: • intestinal type • diffuse type • diffuse carcinoma of linitis plastica type • gastric adenocarcinoma of intestinal type

  7. Borrmann classification: • polypoid • ulcerating • ulceroinfiltrative • infiltrative • gastric adenocarcinoma of ulcerative type • gastric adenocarcinoma of polypoid type

  8. Stage Grouping TNM classification:

  9. Clinical picture • advanced disease at the time of presentation • symptoms at early stage: • fullness in upper abdomen, nausea, anorexia • advanced disease symptoms: • epigastric pain, nausea, vomiting, dysphagia • weight loss • anemia (because of bleeding) • palpable lymph node – supraclavicular fossa (Virchow’s node)

  10. Diagnosis • patient history + physical examination • non-specific findings • lab findings • FBC + LFT • barium meal • ENDOSCOPY (EGD) !!! • staging: • chest X-ray • abdominal US • CT scan

  11. Treatment • endoscopic removal (only early non-ulcerated mucosal lesions) • surgery • chemotherapy • radiotherapy • palliative care

  12. GASTROINTESTINAL STROMAL TUMORS • GI mesenchymal tumors • asymptomatic, found by chance (ulceration, bleeding) • treatment: • surgery • chemotherapy if unresectable

  13. GASTRIC POLYPS • benign • rarely produce symptoms • types: • hyperplastic • adenomatous • cystic gland polyps • inflammatory fibroid polyps • treatment : endoscopic excision

  14. REFERENCES: • Kumar and Clark: Clinical Medicine (7th edition) • B.Vrhovac, B.Jakšić, Ž.Reiner, B.Vucelić: Interna medicina • www.pathconsultddx.com

More Related