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Gastric Secretion. Jack L. Leonard 2004. Johnson Chap. 34-35. Surface mucous cells. Gastric pit. Fundus. Esophagus. isthmus. Parietal cells. Pylorus. Duodenum. Mucous neck cells. neck. Argentaffin cell. Corpus. Pyloric canal. Pyloric antrum. base. Chief cells. The Stomach.

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slide1

Gastric Secretion

Jack L. Leonard 2004

Johnson Chap. 34-35

slide2

Surface mucous

cells

Gastric pit

Fundus

Esophagus

isthmus

Parietal cells

Pylorus

Duodenum

Mucous neck

cells

neck

Argentaffin

cell

Corpus

Pyloric canal

Pyloric antrum

base

Chief cells

The Stomach

Johnson Chap. 34-35

slide3

The Pavlov Pouch Experiment

Johnson Chap. 34-35

slide4

A.

B.

Incision

Closure

Pouch

sham feeding

Vagally innervated

pyloric pouch

0.6

Double-walled

muscosal septum

0.4

Acid Output(mmol/15min)

jejunum

Heidenhain pouch

0.2

0

1

0

2

3

hours

Johnson Chap. 34-35

slide5

Acid Output(mEq T.A./7.5 min)

Time(min)

Histamine Stimulation of Acid Secretion

Johnson Chap. 34-35

slide6

Golgi

Intracellular

canaliculus

Tubulovescular

Membrane

Mitochondria

Intracellular

canaliculus

Tubulovescular

Membrane

Intracellular

canaliculus

Basal folds

Mitochondria

Basement

lamina

Basement

lamina

Stimulated

Unstimulated

Changes in Parietal Cell Morphology with Stimulation

Basal folds

Johnson Chap. 34-35

slide8

ATP

H+

PH/K

ADP

+

PO4

Cl-

K+

K+

JK

JCl

Cl-

K+

Presumed Effects of Stimuli on the Parietal Cell Vesicles

Johnson Chap. 34-35

slide9

Stimulation

Presumed Effects of Histamine on the Parietal Cell

Johnson Chap. 34-35