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Using your basic… HISTOLOGY

Using your basic… HISTOLOGY. ….for UNDERSTANDING DISEASE. 2 things to remember (teacher only). Thankfulness Success. OBJECTIVE. Review basic “NORMAL” histology as examples of how this acts as a “FRAMEWORK” for understanding the primary morphologic classifications of human diseases

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Using your basic… HISTOLOGY

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  1. Using your basic…HISTOLOGY ….for UNDERSTANDING DISEASE

  2. 2 things to remember(teacher only) • Thankfulness • Success

  3. OBJECTIVE • Review basic “NORMAL” histology as examples of how this acts as a “FRAMEWORK” for understanding the primary morphologic classifications of human diseases • DEGENERATIVE • INFLAMMATORY • NEOPLASTIC

  4. “E = mc2”

  5. “All diseases are alterations of normal histology”

  6. How are diseases classified?

  7. Test Question #1What are the 3 primary morphologic classifications of diseases? • Genetic • Collagen • Degenerative • Autoimmune • Inflammatory • Granulomatous • Neoplastic • Toxic • Microbial

  8. Test Question #1What are the 3 primary morphologic classifications of diseases? • Genetic • Collagen • Degenerative • Autoimmune • Inflammatory • Granulomatous • Neoplastic • Toxic • Microbial

  9. INFLAMMATION ACUTE CHRONIC

  10. Test Question #2What are the 2 primary morphologic classifications of inflammation? • Subacute • Granulomatous • Degenerative • Necrotizing • Acute • Pyogenic • Viral • Dysplastic • Chronic

  11. Test Question #2What are the 2 primary morphologic classifications of inflammation? • Subacute • Granulomatous • Degenerative • Necrotizing • Acute • Pyogenic • Viral • Dysplastic • Chronic

  12. NEOPLASM • BENIGN (no “infiltration”) • MALIGNANT (“infiltration”)

  13. Test Question #3What are the 2 primary morphologic classifications of neoplasms? • Metastatic • Dysplastic • Lymphoma • Primary • Benign (non-inflitrative) • Pyogenic • Carcinoma • Malignant (infiltrative) • Sarcoma

  14. Test Question #3What are the 2 primary morphologic classifications of neoplasms? • Metastatic • Dysplastic • Lymphoma • Primary • Benign (non-inflitrative) • Pyogenic • Carcinoma • Malignant (infiltrative) • Sarcoma

  15. DEGENERATION • “Degenerative” diseases are generally characterized by loss of normal histologic structures, WITHOUT significant infiltration of inflammatory cells or proliferation of indigenous cells, such as “degenerative” osteoarthritis (aka, “osteo”arthritis, or atherosclerosis, and are processes which, historically, are often associated with aging, or hormonal “involution” or atrophy or hypoplasia, or slow buildup of substances whi eventually interfere with tissue function.

  16. Test Question #4What are some primary processes associated with “degeneration”? • Aging • Atrophy • Hypoplasia • Infiltration • Hyperplasia • Hypertrophy • Dysplasia • Neoplasm • Hormonal involution

  17. Test Question #4What are some primary processes associated with “degeneration”? • Aging • Atrophy • Hypoplasia • Infiltration • Hyperplasia • Hypertrophy • Dysplasia • Neoplasm • Hormonal involution

  18. How to answer Dr. Schneider’s question

  19. What does all this mean? • “NORMAL” histology • Infiltrationof “polys” or “monos” • Proliferation of inherent cells • Loss of normal cells

  20. Review of Histo Lab Schedule • URINARY • LYMPH • BLOOD/MARROW • RESPIRATORY • CARTILAGE/BONE • ANGIOLOGY • CNS • SKIN

  21. A visual FEEL for the tissue is MUCH more important than remembering the names of all the cells

  22. CORTEX/MEDULLA GLOMERULI/TUBULES/VESSELS

  23. ARTERY GLOM TUB

  24. “NORMAL” ARCHITECTURE: EFFACED or NOT?

  25. SUBCAPSULAR sinus

  26. CELLULARITY, MEGAS, HETEROGENEITY

  27. Heterogeneity, Mat-RBC, Mat-WBC, LYM, PLAS, BLASTS, Fe, METS?

  28. BRONCH, ALVEOLI, VESSELS

  29. BRONCH, ALVEOLI, VESSELS

  30. BONE, CARTILAGE, MARROW

  31. BONE, CARTILAGE, MARROW

  32. V.A.N.

  33. V.A.

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