Apoptosis Execution pathway

1. Apoptosis Execution pathway Apoptosis execution pathway is the same terminal of extrinsic, intrinsic, and perforin/granzyme apoptosis pathways, biochemical changes that characterize apoptosis. As the final stage of apoptosis, it causes cell shrinkage, formation of cytoplasmic blebs and apoptotic bodies and finally phagocytosis of the apoptotic bodies by adjacent parenchymal cells, neoplastic cells or macrophages. leading to the morphological and Extrinsic apoptosis pathway and intrinsic apoptosis pathway are two major pathways lead to apoptosis execution, as well as a perforin/granzyme apoptosis pathway. The extrinsic apoptosis pathway that initiates apoptosis is triggered by a death ligand binding to a death receptor present in the plasma membrane. Intrinsic apoptosis pathway initiates apoptosis by activating Caspase-3 or by cleaving BH3 interacting domain death agonist (Bid) through the Puma and Noxa protein subgroup. Perforin/granzyme apoptosis pathway is the primary signaling pathway used by cytotoxic lymphocytes (Cytotoxic T cells) to eliminate virus-infected and/or transformed cells. Each apoptosis pathway needs specific triggering signals to begin an energy-dependent cascade of molecular events and activates its initiators Caspase-8/9/10 which in turn activates the executioner Caspase-3 in the execution pathway. https://www.creative-diagnostics.com/apoptosis-execution-pathway.htm