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13.10-13.12. Steroidal Hormones. 13.10. Cholesterol forms progesterone. Progesterone is then turned into steroids and sex hormones through bodily processes and lab. . 13.10 What are some of the Physiological Roles of Steroid Hormones. Adrenocorticoid steroids-

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13 10 13 12

13.10-13.12

Steroidal Hormones

13 10
13.10
  • Cholesterol forms progesterone.
  • Progesterone is then turned into steroids and sex hormones through bodily processes and lab.
13 10 what are some of the physiological roles of steroid hormones
13.10 What are some of the Physiological Roles of Steroid Hormones
  • Adrenocorticoid steroids-
    • Adrenal (adjacent to the kidney)
    • Corticoid( Outer cortex of the gland)
    • Cortisol : The major glucocorticoid. It is a hormone primarily used to relieve stress during the body’s physiological reaction to stress.
    • Cortisol (Hydrocortisone) and Cortisone are common steroids used to treat inflammation.
sex hormones
Sex Hormones
  • Testosterone- Male sex hormone, synthesized in the testes from cholesterol.
  • Estradiol – Female sex hormone, synthesized by aromatization of testosterone.
    • Estradiol, along with progesterone regulates the female cyclic process of menstruation.
13 11 bile salts
13.11 Bile Salts
  • Bile salts are synthesized from the oxidation of cholesterol.
  • Formed with the amide bond and creates either glycine or taurine
  • Bile salts are powerful emulsifiers. They disperse lipids in the intestines, similar to soap and dirt.
  • Bile salts are an important way that the body regulates cholesterol levels.
13 12 what are prostaglandins thromboxanes and leukotrienes
13.12What are Prostaglandins, Thromboxanesand Leukotrienes.
  • Prostaglandinns
    • Discovered by Kurzrok and Lieb in the 1930’s
    • They are fatty acid like substances found in seminal fluid that cause the uterus to contract.
    • Created by a ring closure at 8 and 12 in arachidonic acid.
    • Used in treatment of asthma and congestion.
slide7

Thromboxanes are derived from PGH2

  • They are also formed by ring closures, but the ring is a cyclic acetal.
  • Thromboxane is a coagulant. It is blocked by NSAID’s such as aspirin. It can be dangerous in people at high risk for heart attack.
slide8

Leukotrienes are mediators of hormonal responses.

  • They occur mostly in leukocytes.
  • It is 100x stronger than histamines causing extreme muscle contractions in the lungs.
  • It is often treated by LTRs in high risk asthma patients.