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DNA Replication

DNA Replication. DNA template with synthesis of a new strand in the 5' to 3' direction. The 5' triphosphate can only be added to a free 3'OH of deoxyribose. The two antiparallel strands are replicated simultaneously in both directions. RNA primers are used to initiate a new strand

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DNA Replication

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  1. DNA Replication

  2. DNA template with synthesis of a new strand in the 5' to 3' direction. • The 5' triphosphate can only be added to a free 3'OH of deoxyribose. • The two antiparallel strands are replicated simultaneously in both directions. • RNA primers are used to initiate a new strand • The parent strand at the 3' end of the template determines the daughter or leading strand in continuous replication. • The parent strand at the 5' end of the template produces the lagging strand as short pieces of DNA (100-200 nucleotides in eukaryotes and longer in prokaryotes). • The lagging strand fragments are called Okazaki fragments after their discoverer, Reiji Okazaki. • The RNA primers are removed and the fragments are joined by DNA ligase.

  3. Direction of replication

  4. The replication fork 

  5. Conclusions • DNA structure predicts that base sequence determines replication of DNA • If the sequence contains information, then the bases A,T,G, and C must somehow determine aminoacid sequences in proteins. • Mutations in DNA are caused by changes in base sequences.

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