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DNA REPLICATION. WATSON & CRICK’S PROPOSED MECHANISM. COMPETING MODELS FOR DNA REPLICATION. MESELSON-STAHL EXPERIMENT CONFIRMED SEMI-CONSERVATIVE MODEL OF REPLICATION IN LATE 1950s. ssb. ssb. ssb. ssb. ssb. ssb. H. G. C. A. T. G. A. A. G. C. T. G. A. T. T. C. G. A. C.
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MESELSON-STAHL EXPERIMENT CONFIRMED SEMI-CONSERVATIVE MODEL OF REPLICATION IN LATE 1950s
ssb ssb ssb ssb ssb ssb H G C A T G A A G C T G A T T C G A C T C G T A T A C G C G T A C UNWINDING AND UNZIPPING OF DNA
DI 3’ G T P 5’ A C G A A G C T G A C C A A 3’ T T C G A C T DIII C C G G T T A A C C 5’ SYNTHESIS OF THE LEADING STRAND
p p p p p p s s s s s s 3’ 5’ n n n n n n 5’ 3’ 3’ DIII 5’ DNA POLYMERASE WORKING CONDITIONS
A A G C T G A A A A A G G C C T T G G A A A A T T C G A C T T T T T T T T T C C C C G G G G A A A A C C C C T T T T A A G G C C T T G G A A SYNTHESIS OF LAGGING STRAND