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Erytromysiini B

Erytromysiini B. Kuisma Littunen & Antero Myllylä 3.3.2008. Johdanto. Makrolidiluokan antibiootti 14-atominen laktoni Laktonissa 10 kiraliakeskusta Renkaassa kiinni kaksi sokeria: L -kladinoosi ja D -desosamiini Erytromysiini B:n kokonaissynteesit: Woodward et al. 1981

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Erytromysiini B

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  1. Erytromysiini B Kuisma Littunen & Antero Myllylä 3.3.2008

  2. Johdanto • Makrolidiluokan antibiootti • 14-atominen laktoni • Laktonissa 10 kiraliakeskusta • Renkaassa kiinni kaksi sokeria:L-kladinoosi ja D-desosamiini • Erytromysiini B:n kokonaissynteesit: • Woodward et al. 1981 • Martin et al. 2007

  3. Retrosynteesi: Woodward Woodward et al., J Am Chem Soc, 103 (1981) 3210-3213

  4. Retrosynteesi: Woodward Woodward et al., J Am Chem Soc, 103 (1981) 3210-3213

  5. Retrosynteesi: Martin Martin et al., Tetrahedron, 63 (2007) 5709 - 5729

  6. Retrosynteesi: Martin Martin et al., Tetrahedron, 63 (2007) 5709 - 5729

  7. Retrosynteesi: vertailu

  8. Synteesi: Woodward Woodward et al., J Am Chem Soc, 103 (1981) 3210-3213

  9. Synteesi: Woodward Woodward et al., J Am Chem Soc, 103 (1981) 3210-3213

  10. Synteesi: Woodward Woodward et al., J Am Chem Soc, 103 (1981) 3210-3213

  11. Synteesi: Martin 1 Martin et al., J Am Chem Soc, 116 (1994) 4674 - 4688

  12. Synteesi: Martin 1 Martin et al., Tetrahedron, 63 (2007) 5709 - 5729

  13. Synteesi: Martin 1 Martin et al., Tetrahedron, 63 (2007) 5709 - 5729

  14. Synteesi: Martin 2 Martin et al., Tetrahedron, 63 (2007) 5709 - 5729

  15. Synteesi: vertailu

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