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The national resource of large long-term cohort studies

Life-long development of adult health Michael Wadsworth Director of MRC National Survey of Health & Development (the 1946 national birth cohort study). The national resource of large long-term cohort studies. Data collection period. * has or is about to collect DNA.

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The national resource of large long-term cohort studies

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  1. Life-long development of adult healthMichael WadsworthDirector of MRC National Survey of Health & Development (the 1946 national birth cohort study)

  2. The national resource of large long-term cohort studies Data collection period * has or is about to collect DNA

  3. Cohort differences in breast-feeding: % breast-fed for 1 month or more Changing Britain, Changing Lives (2003) ed. Ferri, E., Bynner, J., Wadsworth, M.E.J.

  4. % contribution of food groups to vitamin C intake of 4 year old children in 1950 & 1992/3 Prynne et al 1999

  5. Cumulative death rates 26 to 54 years by father’s social class in 4271 (201 deaths) men and women born in March 1946. Non-manual Manual 26 30 34 38 42 44 48 52 Kuh et al 2002

  6. Maternal/ environmental/ SES influences Educational opportunity Smoking Infant nutrition Infant pulmonary illness Adult respiratory function Early life growth Genetic influences Development of risk to adult respiratory function

  7. Childhood & adult risk, & adult poor respiratory function * Lowest 4th of birth weight & of height at 2 yrs, father’s manual social class, crowding, & pulmonary illness between birth & 2 yrs

  8. Mean BMI in NSHD according to the age of adiposity rebound Wadsworth et al 2005

  9. Other examples of diseases with early life origins of pathways • Schizophrenia • Pre-menopausal breast cancer

  10. Examples of inter and intra cohort differences in exposures Social: maternal age, parental separation, educational opportunity, poverty Environmental: maternal smoking, atmospheric pollution, traffic, pesticides, diet, exercise Pharmacologic oral contraceptive, HRT, & health care: antidepressants, infant survival Disease risk: poliomyelitis, prion disease

  11. Summary of the value of longitudinal studies in health • Showing developmental differences and their lifetime health effects across historic time • Within study research on specific disease outcomes • Inter-cohort comparisons of ageing processes give early insight into population health at entry to later life

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