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BY: Ms. Santoshi Naik Assistant Professor Yenepoya Pharmacy College & Research Centre

BY: Ms. Santoshi Naik Assistant Professor Yenepoya Pharmacy College & Research Centre. 1. What is Syphilis??? Syphilis is a systemic, sexually transmitted disease (STD) caused by the Treponema pallidum bacterium. Modes of transmission.

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BY: Ms. Santoshi Naik Assistant Professor Yenepoya Pharmacy College & Research Centre

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  1. BY: Ms. Santoshi Naik Assistant Professor Yenepoya Pharmacy College & Research Centre 1

  2. What is Syphilis??? Syphilis is a systemic, sexually transmitted disease (STD) caused by the Treponema pallidum bacterium.

  3. Modes of transmission 1) Contact with the chancre during sexual intercourse. Chancre is painless genital ulcers formed during the primary stage of syphilis. 2) From Mother to baby called as Congenital syphilis. 3) Blood transfusion

  4. Causative organismBacteria: Treponema pallidum.

  5. Stages of Syphilis • Primary • Secondary • Latent • - Early latent • - Late latent • Late or tertiary • May involve any organ, but mainly • CNS - Neurosyphilis • CVS - Cardiovascular syphilis

  6. PRIMARYSYPHILIS • (TheChancre) • Incubation period 9-90 days, usually~21 days. • Develops at site ofcontact/inoculation. • Multiplies at the site of entry, a small painless primary lesion called chancreis formed. • Chancre appears externally: penis, vaginalwall,cervix, mouth,anal canal.

  7. CHANCRE PENIS CHANCRE ORAL CHANCRE VAGINAL CHANCRE ANAL CHANCRE

  8. SECONDARY SYPHILIS • Secondary syphilis develops in6-10 weeksafter primarylesion . • Diffuse rashes appear throughout the body.

  9. Symptoms of Secondary syphilis • Skin rashes • Headache • Anorexia • Malaise • Weight loss, • Nausea and vomiting • Slightfever • Nails become brittle

  10. LATENTSYPHILIS After several weeks of secondary syphilis the rashes disappear and the disease becomes latent (dormant & inactive).

  11. Early latent: • The first year after the resolution of primary or secondary lesions. • Infectious • Late latent: • Usually not infectious, except for the pregnant woman, who may transmit infection to her fetus (Congenital Syphilis)

  12. Congenital Syphilis • It usually occurs following vertical transmission of T. pallidum from the infected mother to the fetus in uterus. • Neonates may also be infected during passage through the infected birth canal at delivery.

  13. TERTIARY SYPHILIS • Develops after many years in persons with untreated secondary syphilis. • Appearance of degenerative lesions called GUMMAS (soft swelling) in skin, liver, brain, heart. • CVS – Cardiovascular syphilis • CNS - Neurosyphilis

  14. DIAGNOSIS • Direct examination of clinical specimen by dark-field microscopy or fluorescent antibody testing of sample. • Non-specific or non-treponemalserological test to detect reagin, utilized as screening test only. • Specific Treponemal antibody tests are used as a confirmatory test for a positive reagintest.

  15. PREVENTION AND TREATMENT • Avoidance of sexual contact withdiseased individual. • Use physical barriers andantiseptics. • Antibiotics:Benzathine Penicillin, Procaine Penicillin, Azithromycin, Doxycycline, Tetracycline.

  16. Dr.T.V.RaoMD45

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