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NATURAL KILLER CELLS. WAYNE BORCHERDING MT(ASCP). NATURAL KILLER CELLS. DEVELOPMENT RECEPTORS FUNCTION LABORATORY ANALYSIS. DEVELOPMENT SITE. NATURAL KILLER CELLS. NATURAL KILLER CELLS. DEVELOPMETAL STAGES COMMITMENT MATURATION MIGRATION. DEVELOPMENTAL STAGES .

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NATURAL KILLER CELLS


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natural killer cells

NATURAL KILLER CELLS

WAYNE BORCHERDING

MT(ASCP)

natural killer cells2
NATURAL KILLER CELLS
  • DEVELOPMENT
  • RECEPTORS
  • FUNCTION
  • LABORATORY ANALYSIS
natural killer cells4
NATURAL KILLER CELLS
  • DEVELOPMETAL STAGES
    • COMMITMENT
    • MATURATION
    • MIGRATION
natural killer cells6
NATURAL KILLER CELLS
  • DEVELOPMENTAL STAGES
natural killer cells7
NATURAL KILLER CELLS
  • RECEPTORS
    • CD56 – CD16
    • NK
    • CYTOKINE
    • CHEMOKINE
    • ADHESION
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NATURAL KILLER CELLS
  • RECEPTORS
    • NK
      • KIR – HLA-A-B-C
      • CD94-NKG2 – HLA-G-E
      • NCR (NKp46,p44,p30)
      • LIR (ILT-2)
      • KLR
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CYTOKINE

IL-2

IL-15

IL-1

IL-10

IL-12

IL-18

CHEMOKINE

CCR7

CXCR1,2,3

CX3 CR1

NATURAL KILLER CELLS
natural killer cells10
NATURAL KILLER CELLS
  • BIOLOGICAL FUNCTION
    • CANCER
    • INFECTION
    • PREGNANCY
    • TRANSPLANTATION
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NATURAL KILLER CELLS
  • PREGNANCY
    • MUCOSA AND ARTERIAL FUNCTION
    • PLACENTAL TROPHOBLAST INVASION
natural killer cells13
NATURAL KILLER CELLS
  • LABORATORY ANALYSIS
    • CHARACTERIZATION
      • MORPHOLOGIC
      • FLOW CYTOMETRY
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NATURAL KILLER CELLS
  • LABORATORY ANALYSIS
    • FUNCTIONAL ASSAYS
      • NON-MHC RESTRICTED KILLING
      • ADCC
      • LAK