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ZYOPTIX ® Personalized Treatment Advanced (PTA)

ZYOPTIX ® Personalized Treatment Advanced (PTA). Our best excimer procedure ever. ZYOPTIX Personalized Treatment Advanced (PTA) . PTA - Introduction PTA - Clinical results New ZYOPTIX Advanced Nomogram 1.3 PTA - Summary. ZYOPTIX Personalized Treatment Advanced (PTA). Introduction.

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ZYOPTIX ® Personalized Treatment Advanced (PTA)

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  1. ZYOPTIX® Personalized TreatmentAdvanced (PTA) Our best excimer procedure ever

  2. ZYOPTIX Personalized Treatment Advanced (PTA) • PTA - Introduction • PTA - Clinical results • New ZYOPTIX Advanced Nomogram 1.3 • PTA - Summary

  3. ZYOPTIX Personalized TreatmentAdvanced (PTA) Introduction

  4. PTA - Introduction • PTA is an Aspheric Wavefront Treatment which combines ZYOPTIX Aspheric & ZYOPTIX Personalized • Treatment of preop higher & lower aberrations • Compensation of surgically induced spherical aberrations • Extended Advanced Nomogram across all treatment ranges • With 100Hz & ACE eyetracker technology The ultimate procedure

  5. PT PT PTA PTA - Introduction • PTA is the complete procedure for lower & higher order aberrations without induction of spherical aberration Plano / TS TS also for hypermetropia Myopia, hypermetropia, astigmatism Aspheric Myopia, hypermetropia, astigmatism Myopia only

  6. PTA - Introduction • The evolution of the ZYOPTIX algorithms

  7. PTA - Introduction The best quality of vision available today!

  8. PTA - Introduction • Ease of use - no changes of laser or diagnostic required Personalized Advanced ZYOPTIX Card Next generation Treatment Calculator V 1.3

  9. PTA - Introduction • How does PTA work? Input Algorithm Result Wavefront: Lower & Higher Order Zernike Terms Preop aberration compensation Optical Zone Procedure File Surgery induced aberration comp. Manifest Refraction Advanced Nomogram Base Nomogram

  10. PTA -Introduction • Goals of Personalized Advanced algorithm • PTA integrates knowledge gained in ZYOPTIX Personalized (PT) and ZYOPTIX Aspheric procedures • Optimal postoperative visual performance • Compensates surgically-induced aberrations, especially spherical aberration • Unmatched predictability thanks to the Advanced Nomogram  Now also available for custom hyperopia!

  11. PTA - Introduction • The ultimate algorithm • PTA provides the best visual outcomes thanks to enhanced performance and safety using state-of-art technologies: • Iris recognition for enhanced safety • ACE technology for unsurpassed precision and accuracy • ZYOPTIX Advanced Nomogram for enhanced predictability (now available for customized hyperopia procedures!)

  12. ZYOPTIX Personalized TreatmentAdvanced (PTA) Clinical results – interim analysis !

  13. PTA - Clinical results • Multi-center trial started in March 09 • Asia Eye Institute, Philippines (Dr. Robert T. Ang) • Rutnin Eye Hospital, Thailand (Dr. Noparat Sujaritchan) • Hong Kong Sanatorium and Hospital, Hong Kong (Dr. John S.M Chang Jr) • Contralateral Study of PTA vs PT, both using Advanced Nomogram • Evaluate the safety and effectiveness of the ZYOPTIX Personalized Advanced treatment vs ZYOPTIX Personalized Treatment Algorithm

  14. PTA- Clinical results • Refractive status pre-op

  15. PTA- Clinical results • Refractive status post-op

  16. PTA- Clinical results 1 Day n = 51 1 Week n = 51 1 Month n = 50 • Stability (MRSE over time)

  17. PTA- Clinical results • PTA Predictability (MRSE deviation from target) * B&L study 2008, Dr. Chan, Dr. Ang, Dr. Chang, Dr. Lee, Dr. Wee  Advanced Nomogram enhances predictability

  18. PTA - Clinical results 1 Day n = 51 1 Week n = 51 1 Month n = 50 • Safety

  19. PTA - Clinical results 1 Day n = 51 1 Week n = 51 1 Month n = 50 • Efficacy

  20. N = 50 PTA - Clinical results N = 50

  21. PTA - Clinical results

  22. N = 50 PTA - Clinical results

  23. Cumulative Low Contrast BCVA at 1 Month Post Op 120.0% 100.0% 100.0% 100.0% 84.0% 80.0% % of eyes 60.0% 40.0% 26.0% 20.0% 20.0% 6.0% 4.0% 0.0% 20/16 20/20 20/25 20/40 PTA PT PTA - Clinical results N = 50 N = 50

  24. Analysis diameter at 6mm N = 50 PTA - Clinical results • Q values analysis PTA helps to preserve the natural prolate shape of the cornea!

  25. PTA - Clinical results • Induced Spherical aberration analysis No induction of spherical aberration!

  26. PTA - Clinical results • Surgeon’s feedback • “With the advanced nomogram, the predictability of PTA gets much better” • “The PTA treatment calculator is easy to use” • “Some of my patients reported to be happier with the eye treated with PTA”

  27. ZYOPTIX Personalized TreatmentAdvanced (PTA) New ZYOPTIX Treatment Calculator 1.3

  28. ZYOPTIX Treatment Calculator 1.3 • New features • Faster loading of ote & ate files • Advanced Nomogram is integrated & automatically executed – better ease of use (all Rx range, > 5.0mm wavefront, target Rx, shown in printout) • Improvements for ZYOPTIX Tissue Saving & Aspheric • Display of residual stroma thickness • Optical zone independent from wavefront size • Treatment axis adjustable • No wavefront ate file required for calculation • Support for bilateral calculations • Remove Pachymetry Bug

  29. ZYOPTIX Treatment Calculator 1.3

  30. ZYOPTIX Personalized TreatmentAdvanced (PTA) Summary

  31. PTA- Summary • PTA is the ultimate procedure for patients • PTA provides the best quality of vision • PTA reduces the surgically-induced spherical aberration • PTA minimizes the change of Q values • PTA’s predictability is further improved with the Advanced Nomogram (now also available for hyperopia)

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