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MAPK Signaling

This article delves into the complex world of MAPK signaling pathways influenced by various hormones and growth factors. It examines the roles of Rac1, ERK, JNK, and p38 MAPK in key cellular processes including inflammation, apoptosis, proliferation, and survival. The connections between these pathways and cytokine signaling (e.g., IL-1, TNF) are explored, emphasizing their implications in tumorigenesis and development. Additionally, we discuss how MAPKs communicate with transcription factors like c-Fos and NF-kB, shaping gene expression and cellular responses.

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MAPK Signaling

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  1. TNFR ECM Hormones Hormones RTK GrowthFactorReceptors Rac1 Rac1 GTP GTP GTP GTP MEK5 MEK4/7 MEKK2/3 MEK3/6 JNK1/2/3 JNK1/2/3 ERK1/2 ERK1/2 MLK2/3 MLK3 ERK5 TAK1 Src IRAK FAK TAO1,2 Raf1 A-Raf MNK PKA p38 p38 RIP PKC PKC KSR ASK ASK MSK MSK PAK c-Raf B-Raf TPL-2 RSK MEKK4 MEKK4 MEKK3 MEKK3 MEKK1 MEKK1 MEKK1 MEKK2 PKA PI3K GPCR Cytokines p130CAS TNF IL-1 OSM 2009 ProteinLounge.com TCF/MEF2 MAPKAPK2 Vinculin Paxillin Paxillin POSH JIP1/2/3 Talin CDC42 TRAF6 TRAF2 GRB2 TRADD SOS Rap1 GPCR c-Myc HSF1 c-Fos STATs p53 CREB CREB TCF Elk1 CHOP ATF c-Jun NF-kB NF-kB GrowthFactors GrowthFactors WNK AC AC PLC PLC MP1 BCL2 Ras N Integrin a b b a N IL-1R C SHC SHC C Gα Gb Gg Gα DAG cAMP MAPK Signaling cAMP DAG MAP3Ks MAPKs MEK1/2 Cell MotilityInflammationApoptosisOsmoregulation Cell ProliferationCell SurvivalTumorigenesisDifferentiationDevelopment Gene Expression CellSurvival C ApoptosisInflammationTumorigenesis GeneExpression

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