Cell Signaling

Oct 18, 2012

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Cell Signaling

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Cell Signaling

Introduction. Cells communication is based on chemical signals

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Cell Signaling

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Cell Signaling

Cell Signaling. Modes of Cell-Cell Signaling. Endocrine signaling is a type of cell-cell signaling in which endocrine cells secrete hormones that are carried through the circulation to distant target cells.

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Cell signaling

Cell signaling. Lecture 8. Transforming growth factor (TGF β ) Receptors/ Smad pathway. TGF β receptors. BMP7 TGF β 1, TGF β 2 , TGF β 3 Dpp Inhibins Activins. Autocrine / Paracrine signaling.

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Cell Signaling

Cell Signaling. Lecture 6. GPCRs that activate Phospholipase C- IP3/DAG pathway. Abbreviations. PIP2- phosphatidyl inositol 4,5 – bisphosphate DAG – 1,2- diacylglycerol IP3 – Inositol 1,4,5 – triphosphate PLC – phospholipase C PKC – Protein Kinase C.

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Cell Signaling

Cell Signaling. Lecture 12. NFkB. NFkB (nuclear factor kappa beta) is a transcription factor that plays important roles in the immune system.

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Cell Signaling

Cell Signaling. Lecture 13 and 14. Ligand -activated Notch undergoes 2 cleavages before releasing the transcription factor. ADAM10: A disintegrin and Metalloprotease.

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Cell Signaling

Cell Signaling . Lecture 10. Receptor Tyrosine Kinases. Regulate cell proliferation, differentiation, cell survival and cellular metabolism The signaling molecules that activate RTK are soluble or membrane bound peptide or protein hormones Examples; Nerve growth factor (NGF)

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Cell Signaling

Cell Signaling. Apoptosis, which can be induced by signals from other cells, is the process by which cells do which of the following? A) Move to other parts of the cell (migrate). B) Take on different shapes (morphology) C) Express different genes to take on their final function.

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Cell Signaling

Cell Signaling. “Real Life” Cell Communication: Flight or Fight Response. While watching the movie clip, record at least TWO responses cells have to signals. . Pathways with Friends. Handout Diagram. Steps of Cell Signaling. Reception Signal Transduction Cellular Response. Reception.

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Cell Signaling

Cell Signaling. VI. CELL SIGNALING. Autocrine Signaling. VI. CELL SIGNALING, cont. Coordinates cell activities, development Typically involves 3 steps: Reception – Target cell’s detection of signal molecule due to binding of signal molecule to receptor protein in cell membrane

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Cell-Cell Signaling

Cell-Cell Signaling. Inductive Interactions. Induction: proximate interactions. Close range interactions Inducer Tissue doing the inducing Emits a signal Secreted peptides Cell associated proteins Responder Tissues/cells that receive the signal Change as a result of receiving signal

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Cell Signaling

Cell Signaling. Lecture 25 BSCI 420/421 Oct 30/31, ’02 The 4 Laws of Ecology: “All things are interconnected. Everything goes somewhere. There’s no such thing as a free lunch. Nature bats last.” -Earnest Callenbach A. General principles of Cell Signaling

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Cell Signaling

Cell Signaling. Tidbit Overview. Course: Introductory Cell Molecular Biology. Unit title: Cell Signaling – The Original Social Networking. Class enrollment: 25 – 250 freshman or sophomore Student experience: Near the end of the term. Within the signal transduction unit

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Cell signaling

Cell signaling. Prof.Dr .Gönül Kanıgür. Cell Signaling. All cells receive and respond to signals from their surroundings Signaling molecules that are secreted on the surface of one cell and bind to receptors expressed by the other cells

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Cell-Cell Signaling

Cell-Cell Signaling. Neurotransmitters. Ligand-Gated Na + Channel. Post-synaptic membrane. Target Cell. Signal Transduction Pathway of Target Cell. Receptor Tyrosine Kinase-MAP Kinase Pathway. Receptor Tyrosine Kinase (RTK) Activation. (GEF). (RTK). RTKs Bound to Signal Molecule.

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Cell Signaling

Cell Signaling. Lecture 10. Ras /MAP Kinase Pathway. Receptor tyrosine kinase Cytokine receptors G Protein. Activate this pathway. Ras. Activation of. Ligand. Binding to. Receptor. Formation of. Regulation of. Transcription factor. MAP Kinase. Kinase cascade. Activation of.

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Cell Signaling

Cell Signaling. Communication between cells that are not directly connected. Cell Signaling involves a series of processes…. Sending a signal Transport to target cells Reception Often—signal transduction Response. Sending Signals. Cells synthesize signaling molecules Neurotransmittors

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Cell signaling

Cell signaling. D. Hanahan, R.A. Weinberg The Hallmarks of Cancer. Cell 100: 57-70 (2000). Cell vs. microenvironment. D. Hanahan, R.A. Weinberg The Hallmarks of Cancer. Cell 100: 57-70 (2000). Acquired capabilities of Cancer.

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Cell Signaling

Cell Signaling. Lecture 27 Chapter 16. Eyeless. Cells can exist as single celled organisms or be part of a multi-cellular organism How do they know what is happening around them? Cells do not have ‘eyes’, ‘noses’, or ‘ears’

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Cell Signaling

Cell Signaling. I. OVERVIEW. Soluble chemical signals sent from one cell to another are essential for communication The cellular recipient of the signal is known as target cell and binds the signaling molecule via a protein receptor (on cell surface/cytoplasm or nucleus)

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Cell Signaling

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