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Unraveling Genetics and Chromosomes: A Dive into the Molecular Basis of Life

Explore the fundamentals of genetics and chromosomes, including Mendelian genetics, mutations, meiosis, and the molecular basis of genetic diseases. Dive into the intricacies of chromosomal mutations, biotechnology applications, genomic mapping, and the molecular basis of speciation.

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Unraveling Genetics and Chromosomes: A Dive into the Molecular Basis of Life

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Presentation Transcript

  1. Chapt 8 & 9: Genetics and chromosomes Topics: • What is genetics? • What are chromosomes? • Last review. ……. a nutshell

  2. Basics- of life

  3. Mendelian genetics

  4. Mutations: Mendel and molecular

  5. Meiosis, segregation

  6. Mendelian segregation

  7. Mutations- fine level

  8. Mutation- gross level

  9. [a] molecular basis for genetic disease

  10. Chemical basis of mutation, in life

  11. In lab “classical mutations” • First mutation “white” • UBX

  12. “Classical” mutations

  13. Another view of pathways

  14. [a] biochemical basis of mutation

  15. Genomics basis of mutation

  16. Mendel again

  17. More complicated -dosage -penetrance

  18. Gross level of mutation- chromosomal based

  19. Biotechnology- fingerprinting etc

  20. Mendel and alleles

  21. chromosomes

  22. Painting • False colors

  23. chromosomes

  24. In practice- microscopy

  25. Chromosome mapping- painting

  26. Euk redux of prok: “knock-out”- deletion

  27. More redux: transgenic

  28. Flies, plants

  29. Prok vs Euk genes

  30. Splicing, in a minute

  31. Low vs “High” euk: genes • 80kb genomic

  32. example • Blue= coding • Tan= non

  33. ‘real’ “BINF”

  34. histones Octomer: H2A, H2B, H3, H4 H1

  35. Molecular basis of speciation

  36. Summary- chromosome

  37. Gross mutations- genomic basis for “inborn errors of metabolism”

  38. Chromosome walking/mapping

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