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Methods of developing new secondary metabolites

Methods of developing new secondary metabolites . Vintha M. Thadhani 1 , Syed G. Musharraf 2 , Afshan Begum 2 , M. Iqbal Choudhary 2 & Veranja Karunaratne 3

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Methods of developing new secondary metabolites

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  1. Methods of developing new secondary metabolites Vintha M. Thadhani1, Syed G. Musharraf2, Afshan Begum2, M. Iqbal Choudhary2 & VeranjaKarunaratne3 1Institute of Chemistry, Colombo, Sri Lanka; 2ICCBS, University of Karachi, Pakistan,3University of Peradeniya, Sri Lanka

  2. Lichens Symbiotic association of fungus & algae Worldwide distribution Able to grow under extreme conditions About 20,000 lichen species identified . Still many lichen rich areas remain unexplored Total number may well be close to 100,000.

  3. Secondary metabolites of lichens Occurs exclusively in these symbiotic organisms Even with the advances of analytical methods, there is comparatively less isolation of new lichen metabolites may be due to the limited biosynthetic pathways. Approximately only 1050 lichen metabolites have been isolated to date.

  4. Polyketides- common classes of compounds reported from lichens

  5. Secondary metabolites of lichens- Rich source of biologically active compounds We have already reported various biological activities of lichen compounds including, • antioxidant, • α-glucosidaseinhibitory, • urease inhibitory, • antimicrobial, • cytotoxicity etc

  6. Common secondary metabolites of lichens

  7. Biotransformation of major lichen metabolites-Zeorin Zeorin isolated in 3.4% yield from Cladonia sp. Subjected to various bioassays Patent obtained for α-glucosidase inhibitory activity. Biotransformation through Cumingharellaelegans Yielded 1,3-diacylglycerol & diacylperoxide.

  8. 1,3-diacylglycerol 1-(5-dodecenoyl), 3-(5-decanoyl)glycerol

  9. Diacylperoxide 5-decenoic acid-1,1-diacylperoxide

  10. Semisynthesis of minor metabolites

  11. Complete synthesis of dibenzofurans-Reported

  12. Depsides isolated in major quantities

  13. Smiles rearrangement possible only with erythrin

  14. Analogues of 5-decarboxydibenzofurans

  15. Formal synthesis of pannaricacid derivatives

  16. Some natural analogues of dibenzofuran

  17. Conclusion This study reveals the possibility of conversion of major lichen specific secondary metabolites into new compounds through biotransformation and semi-synthesis.

  18. Thank you

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