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The Role of PLCε in Colorectal Tumorigenesis Revealed through mRNA Analysis and Immunostaining

This study by Li et al. investigates how PLCε expression affects colorectal adenoma development, revealing insights through mRNA levels, DAPI staining, CD31, Gr-1, IGF-1, IL-6, CD44, FGF10, and MMP7 immunostaining techniques.

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The Role of PLCε in Colorectal Tumorigenesis Revealed through mRNA Analysis and Immunostaining

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  1. PLC +/+ +/+ +/- -/- +/+ Min/+ Apc Li, M., et al. Supplementary Fig. 1

  2. Li, M., et al. Supplementary Fig. 2 high-grade low-grade +/+ PLC -/-

  3. PLC +/+ -/- Normal low-grade adenoma high-grade adenoma Li, M., et al. Supplementary Fig. 3 T T N N T T N N

  4. DAPI TUNEL +/+ PLC low-grade -/- high-grade +/+ PLC -/- Li, M., et al. Supplementary Fig. 4

  5. PLC +/+ -/- low-grade high-grade Li, M., et al. Supplementary Fig. 5

  6. DAPI CD31 +/+ PLC low-grade -/- +/+ PLC high-grade -/- Li, M., et al. Supplementary Fig. 6

  7. DAPI Gr-1 +/+ PLC low-grade -/- +/+ PLC high-grade -/- Li, M., et al. Supplementary Fig. 7

  8. IGF-1 IL-6 CD44 7 5000 25 6 4000 20 5 3000 15 Relative mRNA levels 4 3 2000 10 2 1000 5 1 0 0 0 +/+ +/+ +/+ +/+ +/+ -/- -/- -/- -/- -/- PLCe PLCe PLCe PLCe PLCe FGF10 MMP7 7 6 8 5 Relative mRNA levels 6 4 3 4 2 2 1 0 0 Li, M., et al. Supplementary Fig. 8 *** *** *** *** **

  9. anti-PLC Alcian Blue Li, M., et al. Supplementary Fig. 9

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