


Loading in 2 Seconds...
Loading in 2 Seconds...
To “Pee” or not to “Pee”—the KIDNEY in health and disease. “It is no exaggeration to say that the composition of the blood is determined not by what the mouth takes in but by what the kidneys keep.” Homer W. Smith (1895-1962). Some numbers….
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
“It is no exaggeration to say that the composition of the blood is determined not by what the mouth takes in but by what the kidneys keep.” Homer W. Smith (1895-1962)
*uncomplicated UTI if resistance to TMP/SMX is ≥20%
1) the endothelial cells of the glomerulus
2) the basement membrane between the glomerulus and the,
3) epithelial cells of Bowman’s capsule
2. The basement membrane (a glycoprotein layer)
3. The fenestrated wall (epithelial) cells of Bowman’s capsule into the first part of the tubule (the proximal tubule)(epithelial cells)
Lupus nephritis 2) diabetic nephropathy 3) nephrotic syndrome
Glom BM BC PCT
The glomerular filtration membrane3
2
3
1
The statin “sisters”…
ACE (angioconverting enzyme) converts I to….
ALDOSTERONE
ACE--
ALDOSTERONE
(vasodilated via
(prostaglandins)
glomerulus
(vasoconstricted via
(angiotensinII)
glomerulus
Prostaglandins
filter
Angiotensin II
Toilet
and/or hypertension
boost prostaglandins and
vasodilate the afferent
arteriole
hypertension increase
angiotensin II and vaso-
constrict the efferent
arteriole
causes microalbuminuria
Microalbuminuria --10-fold > risk of RD & CKD)
PRILS
ARBs
What do YOU do?
newborn (0.3-1.0)
infant (0.2-0.4)
child (0.3-0.7)
Adolescent (0.5-1.0)
Adult Male (0.6-1.3)
Adult Female (0.5-1.2) (women have 15% less muscle mass than men, hence serum creatinine is lower)
Elderly patients—less muscle mass, decreased filtration due to aging kidney