1 / 14

Delgerdalai Khashbat, Takashi Abe, Ganbold Mungunbagana,

THE CORRELATIONS OF 3D PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING AND DYNAMIC SUSCEPTIBILITY CONTRAST PERFUSION MRI IN BRAIN TUMOR S. Delgerdalai Khashbat, Takashi Abe, Ganbold Mungunbagana, Saho Irahara, Seiji Iwamoto, Naoto Uyama, Youichi Otomi, Masafumi Harada

sergioa
Download Presentation

Delgerdalai Khashbat, Takashi Abe, Ganbold Mungunbagana,

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. THE CORRELATIONS OF 3D PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING AND DYNAMIC SUSCEPTIBILITY CONTRAST PERFUSION MRI IN BRAIN TUMORS Delgerdalai Khashbat, Takashi Abe, Ganbold Mungunbagana, Saho Irahara, Seiji Iwamoto, Naoto Uyama, Youichi Otomi, Masafumi Harada Department of Radiology, Institute of Health Biosciences, TokushimaUniversity Graduate School

  2. ☑ The author has no conflict of interest to disclose with respect to this presentation.

  3. Background • Arterial sipin labeling (ASL) is non contrast perfusion MR method for quantitativily measuring cerebral blood flow (CBF) and its an alternative method to Dynamic susceptibility contrast enhanced perfusion (DSC) MRI to estimate brain tumor perfusion (1). • DSC MRI is frequently used perfusion method to evaluate various neurological diseases that technique relies on the first passage of contrast agent through to the brain tissue (2). • Recently DSC Time to maximum (Tmax) is introduced as a reliable parameter for evaluation of cerebral hemodynamics (3). However, the findings of Tmax in brain tumors and correlation between ASL and Tmax in brain tumors are not studied yet. • Hanna Jarnum et al, Neuroradiology (2010) 52:307-317 • Wolf RL et al, Stroke. 2007 Jul;4(3):346-59. • 3. Fernando Calamante et al; Stroke. 2010;41:1169-1174

  4. Purpose • The purpose of the study was to compare 3D ASL with DSC MRIparameters including Tmax in patients with brain tumors

  5. Materials and methods: Patients • A total of 31 patients with brain tumor underwent MRI examination at theTokushima University Hospitalin 2010. • HGG-19, LGG-4, PCNSL-4, Mets-3, Hemangioblastoma-1 • male 14, female17, mean age 58.4 (19-77) MRI imaging (3T MRI, Discovery 750, GE Healthcare, WI) • ASL performed with pseudocontinuous labeling,background suppression and a stack of spirals 3D fast spin echo imaging sequence; • ASL were following paremeter: 512 sampling points on eight spirals, field of view (FOV): 24 cm, reconstructed matrix: 64×64, TR: 4632 ms, TE: 10.5 ms, number of excitation (NEX): 2, post labeling delay: 1525ms, slice thickness: 4 mm, number of slices: 36 and acquisition time: 3:15 min.

  6. Materials and methods: • rCBV, rCBF,Tmax and MTT are obtained by DSC MRI. • DSC–MRI was performed using aGE-EPI (gradient-echo, echo-planar imaging); FOV = 240 mm,TR/TE = 1990/50 msec,Matrix size = 128 x 128, FA = 90 degrees, ASSET factor = 2,Number of Averages = 1, slice thickness = 3/1 mm, number of slices = 20, acquisition time = 100 sec ( 50 phases ) • In addition, T1WI, T2WI, FLAIR, DWI and post contrast T1WI • Data Analysis • Data analysis was performed on AW workstation 4.6 (GE Healthcare, WI) • ROI’s were placed within maximal signal enhancement of tumor lesion on CE T1WI and were coregistered to all perfusion maps. Tumor perfusion values were calculated by mean value of tumor ROI in ASL, DSC rCBV, rCBF, Tmax. • Absolute mean ASL-CBF value was aslo estimated from the tumor ROI. • Statistical Analysis • SPSS 20.0; Pearson’s correlation, Independent T-test; • A Value of P<0.05 was considered significant.

  7. Result (1).The correlationsbetween ASL and DSC perfusion MRI parameters in brain tumors Spearman’s rank correlations (No.of cases=31) **.P<0.01, *.P<0.05

  8. The correlations of ASL and DSC perfusion MRI parameters in brain tumors r=0.652, p< 0.0001 r=0.738, p< 0.0001 r=-0.417, p= 0.019 • Spearman’s correlation (2-tailed). No of cases 31

  9. CE-T1WI ASL CBF DSC rCBV Glioblastoma multiforme in a 52 year old man DSC rCBF DSC Tmax

  10. Result (2). The differences of the perfusion parameters between grade III glioma, GBM and malignant lymphoma p=0.015 p=0.016 p=0.019 p=0.020 p=0.036 p=0.017 p=0.247 p=0.356 Independent T test (two-tailed)

  11. Result (3) p=0.016 p=0.003 • Absolute CBF was also significant to differentiate GBM from grade III glioma (p=0.003) and malignant lymphoma (p=0.016) . • There were not any signifcant differences between HGG vs LGG, GBM vs metastasis in thus of perfusion parameters.

  12. Discussion • ASL is strongly correlated with rCBF and rCBV in this study. In addition, ASL is correlated with Tmax in brain tumors, but not correlated with MTT. • ASL and Tmax parameter may reflects by transit delay, dispersion that is contrary to rCBF and rCBV. The calculated Tmax value is found to reflect a combination of delay, dispersion and a lesser degree mean transit time(MTT) (3). • Absolute ASL-CBFand ratio of ASL-CBF both can differentiate GBM from grade III glioma and malignant lymphoma as well as rCBV, rCBF. • Absolute ASL-CBF is may conveniece perfusion method in clinical practice by spending less time compared with normalized relative perfusion values which derrived from DSC perfusion MRI. 3. Fernando Calamante et al; Stroke. 2010;41:1169-1174

  13. Conclusion • 3D ASL could be used an alternative perfusion method to the DSC MRI for evaluation of brain tumors. But ASL may be influenced by vascular delay and dispersionwhich are not contained in rCBV and rCBF derived DSC MRI.

  14. FIREWORKS (HANABI), TOKUSHIMA, JAPAN THANK YOU FOR YOUR ATTENTION

More Related