1 / 24

Microarray Data Analysis of Adenocarcinoma Samples: Surgery and Bronchoscopy Findings

This study analyzes microarray data from adenocarcinoma samples, comparing gene expressions across different groups: 62 total surgeries, 38 total bronchoscopies, with smokers and nonsmokers. Key findings showcase the glycolytic pathways in cancer cells linked to mitochondrial injury and therapeutic resistance. Specific genes such as VDAC1, UBE4B, and others are highlighted for their roles in smoker versus nonsmoker comparisons in male and female cohorts. The research underscores the impact of smoking on gene expression in adenocarcinoma for both surgical and bronchoscopic interventions.

sema
Download Presentation

Microarray Data Analysis of Adenocarcinoma Samples: Surgery and Bronchoscopy Findings

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Microarray data analysis of adeno- samples Total Surgery: 62 Adeno: 38 Total bronchoscopy: 110 Adeno: 43 8 Yes vs. 23 No 17 Yes vs. 14 No Male: 5 Female: 18 Male: 6 Female: 2 Male: 3 Female: 13 Male: 15 Female: 3

  2. Male-adeno-(surgery): smokers (6) vs. nonsmokers (5) 26 genes

  3. Male-adeno-(surgery): smokers vs. nonsmokers Cancer cells generally exhibit increased glycolysis for ATPgeneration due in part to mitochondrialrespiration injury and hypoxia, which are frequently associatedwith resistance to therapeutic agents.

  4. Male-adeno-(surgery): smokers vs. nonsmokers

  5. Male-adeno-(surgery): smokers vs. nonsmokers VDAC1 UBE4B TRRAP TRM27 RPL5 POLR3C PGK1 ATP6V1A CHRNA5 NR4A2 NONO GNB2L1 POLE4

  6. Male-adeno-(surgery): smokers vs. nonsmokers

  7. Male-adeno-(Bronchoscopy): smokers (15) vs. nonsmokers (3)

  8. Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  9. Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  10. Male-adeno-(Bronchoscopy): smokers vs. nonsmokers PRKCDBP FJX1 DNM3 COL13A1 APL15 SELE CST4

  11. Male-adeno-(Bronchoscopy): smokers vs. nonsmokers

  12. Male-adeno-(bronchoscopy+surgery): smokers (21) vs. nonsmokers (8)

  13. Male-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  14. Male-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  15. Female-adeno-(bronchoscopy): smokers (3) vs. nonsmokers (10) 20 genes

  16. Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  17. Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  18. Female-adeno-(bronchoscopy): smokers vs. nonsmokers

  19. Female-adeno-(Surgery): smokers (2) vs. nonsmokers (18)

  20. Female-adeno-(bronchoscopy+surgery): smokers (31) vs. nonsmokers (5)

  21. Female-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  22. Female-adeno-(bronchoscopy+surgery): smokers vs. nonsmokers

  23. GSE10072 nm1790

More Related