'Prp sc' presentation slideshows

987 views • 78 slides

MATHEMATICAL MODELS OF PRION PROLIFERATION

MATHEMATICAL MODELS OF PRION PROLIFERATION. Yeast cells infected by prions. (http://www.mos.org/cst/article/368/7.html). Prion Proliferation Models Research Team. Meredith Greer (Bates College, Lewiston, Maine, USA) Hans Engler (Georgetown University, Washington, DC, USA)

546 views • 42 slides

Defective Interfering RNAs

Defective Interfering RNAs. DI RNAs are formed by deletion and recombination during viral RNA replication. They require helper virus to replicate and to be packaged into DI particles. They must retain all cis-acting signals required for replication and packaging.

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BSE Surveillance in the USA

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PRIONS THE INFECTIOUS PROTEINS

PRIONS THE INFECTIOUS PROTEINS. Paras Yadav*, Jaspreet Singh Arora*, Sachinandan De*, Tirtha Kumar Datta*, Surender Lal Goswami*, Aarti Bhardwaj $ , Shalini Jain # and Hariom Yadav #

552 views • 36 slides

Transmissible Spongiform Encephalopathies (TSEs) a.k.a. Prion Diseases

Transmissible Spongiform Encephalopathies (TSEs) a.k.a. Prion Diseases. Transmissible ? can be spread Spongiform ? resembling a sponge Encephalopathies ? disorders/diseases of the brain. Characteristics of TSEs.

654 views • 36 slides

Scenarios for Protein Aggregation

Ruxandra I. Dima. F. Massi (Columbia) D. Klimov (GMU) J. Straub (BU) B. Tarus (BU) M. S. Li (Poland). Scenarios for Protein Aggregation. Illustrations using A ? peptides and PrP C as examples. (PrP C ). A ?-peptides. DIMACS meeting Rutgers University

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Protein Misfolding Can Have Deadly Consequences

Protein Misfolding Can Have Deadly Consequences. Yu Tiantian Li Yihan. In April 1996 a paper was published in the medical journal Lancet that generated widespread alarm in the populations of Europe.

479 views • 33 slides

Prion Project

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Prions Genetic Polymorphism & Susceptibility

Prions Genetic Polymorphism & Susceptibility. Carlos Francisco Mendoza. Human Prion Diseases. Comparison of Prp C and Prp Sc. Evidence Supports the Prion Hypothesis. Genetic Polymorphism. RPSA Polymorphisms have no direct influence on susceptibility to sporadic CJD. Susceptibility.

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Transmissible Spongiform Encephalopathies

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The Exam: Friday Sept. 2 Will start at what time 8 AM Will end at 10:55 AM, sharp Format

The Exam: Friday Sept. 2 Will start at what time 8 AM Will end at 10:55 AM, sharp Format No calculator needed. Know scientific notation: 10 3 = 1000 10 -3 = 0.001, 1/10 6 = 10 -6 8 M - = 8 per molar 8 M -. sec - = 8 per molar per second Closed notes/Closed book

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CLINICAL ASPECTS OF BIOCHEMISTRY NEURODEGENERATIVE DISEASES Prion diseases Alzheimer's disease

CLINICAL ASPECTS OF BIOCHEMISTRY NEURODEGENERATIVE DISEASES Prion diseases Alzheimer's disease. SOME PRION DISEASES TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES. SPONGIFORM BRAIN TISSUE. From Prusiner (1998). HOW CAN PROTEINACEOUS PARTICLE BE INFECTIOUS?.

505 views • 24 slides

Transmissible Spongiform Encephalopathies

Transmissible Spongiform Encephalopathies. Prion Diseases. Classification of TSEs. Characteristic features of TSEs. Long asymptomatic incubation period (years) Fatal neurodegenerative disease Characteristic pathological changes in the brain (vacuoles).

411 views • 20 slides

Proteins as Pathogens

247 views • 19 slides

Proteins as Pathogens

242 views • 19 slides

PRIONS

PRIONS. 221. PRIONS. Infectious agent made of proteins WHICH ARE NOT ASSOCIATED WITH A NUCLEIC ACID Infect by folding and unfolding into irregular conformations The abnormally folded molecule is able to convert proteins into correctly folded form This process perpetuates the infection.

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Mouse Prion Protein Domain PrP(121-231)

Mouse Prion Protein Domain PrP(121-231). Andreas Razen Geometric Computations in Molecular Biology 2 May 2007. Prion Protein. Located in cell surface (brain, nervous system) Protects cell against oxidative stress (free radicals lacking electrons)

238 views • 11 slides

Mouse Prion Protein Domain PrP(121-231)

Mouse Prion Protein Domain PrP(121-231). Andreas Razen Geometric Computations in Molecular Biology 2 May 2007. Prion Protein. Located in cell surface (brain, nervous system) Protects cell against oxidative stress (free radicals lacking electrons)

229 views • 11 slides