Chapter 10. Nucleotides and Nucleic Acids Biochemistry by Reginald Garrett and Charles Grisham. Essential Question.By MikeCarlo
Beyond the Human Genome: Transcriptomics. Dr Jen Taylor Henry Wellcome Centre for Gene Function Bioinformatics Department of Statistics firstname.lastname@example.org. Beyond the Human Genome: 1995 Human Genome sequencing begins in earnest “Mapping the Book of Life” 1999 Human GenomeBy thina
Non-coding RNA gene finding problems. Outline. Introduction RNA secondary structure prediction RNA sequence-structure alignment. Central dogma cont’d. Central dogma cont’d. Non-coding RNA (ncRNA) RNA acting as functional molecule. Not translated into protein. Non-coding RNA geneBy ilya
Genome organization & its genetic implications. Lander , ES (2011) Initial impact of the sequencing of the human genome. Nature 470:187 Feuillet, C, JE Leach, J Rogers, PS Schnable , K Eersole (2011) Crop genome sequencing: lessons and rationales. Trendt Plant Sci 16:77.By lerato
ncRNAs. What Genomes are Telling Us. ncrna.ppt. ncRNA genes are difficult to discover!. small an annotational and statistical concern no ORFs and no polyadenylation must be identified by paralogy/orthology novel members not readily discovered from sequenceBy garima
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Small Nucleolar RNA. Megan Salt BMS 265 – Macromolecules Special Topics in Nucleic Acids. Discovery of snoRNAs. U3 snoRNA. First snoRNA found in late 1960’s (U3) Band representing sn and snoRNAs seen from rat nuclei High uridine content led to naming convention. Wikipedia.
Regulatory RNAs. Cells produce several types of RNA. REGULATION BY RNAs IN BACTERIA. Activation and repression of translation by sRNAs (bacterial small RNAs). Ribo -switches reside within the transcripts of genes whose expression they control through changes in secondary structure.
Catalytic RNAs. The revenge of a mistreated molecule. The Modern Biology Dogma. DNA stores information Proteins perform all the activity RNA acts as intermediate between DNA and Proteins. The Discovery of Catalytic RNAs. Kruger, Cech et al Self-splicing RNA. Cell, 1982
RNAs não codificadores. Definição, funções e identificação através da bioinformática Gabriel Zaniboni. RNAs Não Codificadores. Molécula de RNA funcional, ou seja, não precisa ser traduzida em proteína para que a informação contida em sua sequência exerça sua função; Produtos de genes de RNA;.
Defective Interfering RNAs. DI RNAs are formed by deletion and recombination during viral RNA replication. They require helper virus to replicate and to be packaged into DI particles. They must retain all cis-acting signals required for replication and packaging.
Short hairpin RNAs. Dave Lyons May 2009. Short hairpin RNAs. Discovery of interfering RNAs shRNAs in biology shRNAs in medicine. Short hairpin RNAs. Discovery of interfering RNAs shRNAs in biology shRNAs in medicine. Discovery of RNAi. 1990. 2000. 2010. “Invention” of shRNA. 2000.
Non-coding RNAs ( ncRNAs ). ncRNAs : A brief intro Long non-coding RNAs ( lncRNAs or lincRNAs ): >200 bp miRNAs : Biogenesis, measurement, functional analysis, & utility. Key references: Prensner JR & Chinnaiyan AM. The emergence of lincRNAs in cancer biology. Cancer Disc. 1: