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Genetics for Epidemiologists Lecture 7: Replication and Functional Studies

Genetics for Epidemiologists Lecture 7: Replication and Functional Studies

Genetics for Epidemiologists Lecture 7: Replication and Functional Studies. National Human Genome Research Institute. U.S. Department of Health and Human Services National Institutes of Health National Human Genome Research Institute. National Institutes of Health.

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684 views • 61 slides
10/07/08 Journal Club Simone Sanna-Cherchi

10/07/08 Journal Club Simone Sanna-Cherchi

10/07/08 Journal Club Simone Sanna-Cherchi. OUTLINE. Basis of Admixture Mapping as strategy do identify disease-associated genes Papers Implications of MYH9 association to FSGS and non-diabetic ESRD in African Americans. LINKAGE DISEQUILIBIRUM.

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594 views • 41 slides
QTL Mapping in Heterogeneous Stocks

QTL Mapping in Heterogeneous Stocks

QTL Mapping in Heterogeneous Stocks. Talbot et al , Nature Genetics (1999) 21:305-308 Mott et at, PNAS (2000) 97:12649-12654. QTL Detection in F2 to get 30cM resolution. Chromosome 1. Chromosome 15. Chromosome 10. Gershenfeld et al Behav Genetics, 1997. Heterogeneous Stocks (HS).

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536 views • 39 slides
QTL Mapping in Heterogeneous Stocks

QTL Mapping in Heterogeneous Stocks

QTL Mapping in Heterogeneous Stocks. Talbot et al , Nature Genetics (1999) 21:305-308 Mott et at, PNAS (2000) 97:12649-12654. QTL Detection in F2 to get 30cM resolution. Chromosome 1. Chromosome 15. Chromosome 10. Gershenfeld et al Behav Genetics, 1997. Heterogeneous Stocks (HS).

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394 views • 39 slides
Mapping Genes for SLE: A Paradigm for Human Disease?

Mapping Genes for SLE: A Paradigm for Human Disease?

Mapping Genes for SLE: A Paradigm for Human Disease?. Stephen S. Rich, Ph.D. Department of Public Health Sciences Wake Forest University School of Medicine. Simple vs Complex Traits. Simple Traits -rare -single gene (Mendelian) -severe mutations -large phenotypic effect. Complex Traits

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431 views • 31 slides
I.Moreno, J. Tomkins, P. Hurtado, E. Okogbenin, A. Dixon & M.Fregene

I.Moreno, J. Tomkins, P. Hurtado, E. Okogbenin, A. Dixon & M.Fregene

Progress in Positional Cloning of CMD2 the Gene that Confers High level of Resistance to the Cassava Mosaic Disease (CMD). I.Moreno, J. Tomkins, P. Hurtado, E. Okogbenin, A. Dixon & M.Fregene Global Cassava Partnership GCP-I July 22, 2008. Outline. Introduction Fine Mapping

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457 views • 30 slides
Linkage Studies (1a)

Linkage Studies (1a)

Linkage Studies (1a). Linkage Studies (1b). Power of 595 independent sib pairs (Koller et al. 2000) and 53 pedigrees composed of 630 individuals (Deng et al. 2002). . A: recombination fraction=0. B: recombination fraction=0.05. Linkage Studies (2). Linkage Studies (3).

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371 views • 23 slides
Regions of the Canine Genome Associated with Osteosarcoma Identified by a Whole Genome

Regions of the Canine Genome Associated with Osteosarcoma Identified by a Whole Genome

Regions of the Canine Genome Associated with Osteosarcoma Identified by a Whole Genome Case-Control Association Study. Kenine E Comstock , Elinor Karlsson, Claire Wade, Evan T Keller, Eric Lander, Laurence Baker, Kerstin Lindblad-Toh

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396 views • 22 slides
Genetics of speciation in Mimulus

Genetics of speciation in Mimulus

Genomic tools for positional cloning. Comparative mapping. Overview. Positional cloning of the QTL in these two species pairs will be facilitated by generating genetic and physical maps that are anchored by comparative mapping markers (see next section).

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210 views • 1 slides

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