'Base excision repair' presentation slideshows

Roslyn Franklin

Roslyn Franklin. http://www.sdsc.edu/ScienceWomen/franklin.html. How would YOU go about determining the mechanism of DNA replication?????. What would a geneticist do?. What would a biochemist do?. Figure 5-31 Action of DNA polymerases. Page 99.

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1 ? 3 ?? 5 ??????????? 1 ? 3 ??????????? ???? 2007 ? 1 ? 10 ???? ???????????????????????????????????????? dkniu@bnu.edu.cn dengkeniu@hotmail.com. Chapter 16 Mutations and DNA Repair.

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DNA repair by:S.Solali

DNA repair by:S.Solali. Types of DNA Damage. Deamination: (C ? U and A? hypoxanthine) Depurination: purine base (A or G) lost T-T and T-C dimers: bases become cross- linked, T-T more prominent, caused by UV light (UV-C (<280 nm) and UV-B (280-320 nm)

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Susceptibility Markers

Susceptibility Markers. Susceptibility Markers. Susceptibility markers represent a group of biological markers, which may make an individual susceptible to cancer. These markers may be genetically inherited or determined or acquired. They are independent of environmental exposures.

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Susceptibility Markers

Susceptibility Markers. Susceptibility Markers. Susceptibility markers represent a group of biological markers, which may make an individual susceptible to cancer. These markers may be genetically inherited or determined or acquired. They are independent of environmental exposures.

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DNA REPAIR

BIOCHEMISTRY

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DNA Repair and Mutations

DNA Repair and Mutations. Chemical reactions and some physical processes constantly damage genomic DNA At the molecular level, damage usually involves changes in the structure of one of the strands Vast majority are corrected by repair systems using the other strand as a template

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Snapshot of the next four weeks

BEH.109: Laboratory Fundamentals in Biological Engineering. MODULE 3 Eukaryotic Cells as Phenotypic Indicators: The use of RNAi to modulate gene expression DAY 3. Snapshot of the next four weeks

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DNA damage and repair

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The Mutability and Repair of DNA

The Mutability and Repair of DNA. (transition). (transversion). purine. pyrimidine. Replication errors and their repair. The nature of mutations: Point mutation. 1. Switch of one base for another:. 2. insertion or deletion of a nucleotide. Drastic changes in DNA. Deletion Insertion

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Cellular response to DNA damage

Cellular response to DNA damage. Reponse Mechanisms Tolerance of DNA damage Replicative bypass of template damage Translesion DNA synthesis Reversal of DNA damage Enzymatic photoreactivation

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Bacterial Physiology (Micr430)

Bacterial Physiology (Micr430). Lecture 17 Bacterial Responses to Environmental Stress (Text Chapter: 19). Environmental Stress and Response.

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Spontaneous Damage to DNA

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Single and Double-strand Break Repair

Single and Double-strand Break Repair. Andrew Pierce Microbiology, Immunology and Molecular Genetics Toxicology University of Kentucky. TOX 780. Single-strand Nicks. Any covalent disruption in the phosphodiester backbone in ONE of the two DNA strands in double-helical DNA.

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Base Excision Repair

Base Excision Repair. Base Excision Repair (BER). Nature, 411:366-374, 2001.

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EH Rubinson et al. Nature 000 , 1-6 (2010) doi:10.1038/nature09428

Base excision repair of alkylated DNA by AlkD. EH Rubinson et al. Nature 000 , 1-6 (2010) doi:10.1038/nature09428.

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