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Atherosclerotic Lesion Area in Aortic Sinus of apoE-/- Mice

Study of atherosclerosis in mice with and without CRP showing plaque images and serum analyses. Research by Gideon M. Hirschfield et al. published in PNAS 2005.

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Atherosclerotic Lesion Area in Aortic Sinus of apoE-/- Mice

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  1. Atherosclerotic lesion area within the aortic sinus of apoE -/-and apoE -/-- hCRP+mice Gideon M. Hirschfield et al. PNAS 2005;102:8309–8314

  2. Typical atherosclerotic plaques in the aortic sinus of an apoE -/-- hCRP+ mouse at 20 weeks (A) Oil red O stain. (B) Hematoxylineosin stain (C) Immunostain with anti-human CRP antibody. (D) Immunostain with anti-mouse C3 antibody. (E) Immunostain with anti-human CRP antibody preabsorbed with immobilized pure human CRP, showing complete absence of staining observed in C.(F) Anti-mouse C3 antibody preabsorbed with immobilized mouse C3, showing complete absence of staining observed in D Gideon M. Hirschfield et al. PNAS 2005;102:8309–8314

  3. Serum concentrations of mouse SAP and human CRP in apoE -/-and apoE +/+mice with and without transgenic human CRP Gideon M. Hirschfield et al. PNAS 2005;102:8309–8314

  4. Serum concentrations of estradiol and testosterone at age 50 weeks in apoE -/-and apoE +/+mice with and without transgenic human CRP Gideon M. Hirschfield et al. PNAS 2005;102:8309–8314

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