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Mendelian Explanation of a Quantitative Trait Very small:Small:Medium : Large : Very Large1 4 6 4 1
Study Question 3 How many discrete lengths would you predict to be possible if there were four identical Height genes?
ComplementationMultiple Infection Multiplicityof Infection Phage/Hosts
Study Question 4 • 5 mutants of phage T2 • Mutants forms tiny plaques • Complementation tests - coinfect E. coli with pairs • How many genes are required for the wildtype phenotype?
Study Question 5-7 Cross female #34 extra hairy x male #43 (Curly hair) Possible genotypes of parents?Genotypes of F1 progeny? One gene hypothesis #34: EE x #43: CC EC Two gene hypothesis #34: EE ++ x #43: ++ CC E+ C+ Two gene hypothesis/one X-linked X+XE C+XE Y C+ #34: XEXE++ x #43: X+Y CC
Recombination Nicked strand invades other chromosome One strand nicked Homologous chromosomes pair Other strands break Recombination complete
Recombination No change (sequences are identical except for sites of mutation)
Recombination Two novel DNA’s, different from parents
Complementation vs Recombination ComplementationRecombination acts through protein acts through DNA temporary permanent efficient rare useful to define genes useful to map genes