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Central Brain Tumor Registry of the United States (CBTRUS) cbtrus

Patterns of Brain and CNS Tumor Incidence and Survival in U.S. Adolescents and Young Adults Ages 15-34. Central Brain Tumor Registry of the United States (CBTRUS) www.cbtrus.org. Therese A. Dolecek, Ph.D. Senior Research Associate Bridget J. McCarthy, Ph.D. Principal Investigator.

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Central Brain Tumor Registry of the United States (CBTRUS) cbtrus

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  1. Patterns of Brain and CNSTumor Incidence and Survival in U.S. Adolescents and Young AdultsAges 15-34

  2. Central Brain Tumor Registry of the United States (CBTRUS)www.cbtrus.org Therese A. Dolecek, Ph.D.Senior Research AssociateBridget J. McCarthy, Ph.D.Principal Investigator

  3. Proportional Contribution ofBrain & CNS Tumors Relative to All TumorsAmong Ages 15-34, SEER 2004-2006

  4. Overall Study Goal: To determine brain and CNS tumor incidence and survival patterns among U.S. adolescents and young adults.

  5. Study Data Sources Incidence: All Primary CBTRUS 2000-2004 SEER 2004-2006 Survival: Malignant Primary SEER 1973-2006

  6. Demographic Characteristics • Age Groups: 15-19, 20-24, 25-29, 30-34 • Gender: Males, Females • Race/Ethnic Groups: Hispanics Black, non-Hispanics Other, non-Hispanics White, non-Hispanics

  7. Brain and CNS Tumor Definitions - Behavior Non-Malignant (0, 1) Passed in 2002 - Public Law 107-206 Required collection of benign (0) and uncertain (1) behavior starting with cases diagnosed in January 2004 Malignant (3) Note: Pilocytic astrocytomas are included in malignant category.

  8. Statistical Methods Measures: • Frequencies • Age-specific Rates • Annual Percentage Change • Kaplan-Meier Survival Method for Cohort and Period Analysis • Proportions for 5-year survival All Analyses Performed Using SEER*Stat Version 6.5.1

  9. Brain and CNS TumorAge-Specific Incidence Counts and Rates by BehaviorCBTRUS, 2000-2004 Rates are per 100,000 person-years. Note: Pilocytic astrocytomas are included in malignant category.

  10. Age-Specific Incidence Rate Proportionate Distributions by Behavior CBTRUS, 2000-2004

  11. Male to Female Incidence Rate Ratios by BehaviorCBTRUS, 2000-2004 Non-Malignant Malignant

  12. Age-Specific Incidence Rates by Race/Ethnicity CBTRUS, 2000-2004

  13. Top 5 Primary SitesAge-Specific Incidence RatesCBTRUS, 2000-2004

  14. Proportionate Distribution of Age-Specific Incidence Rates by Histology Grouping for Malignant BehaviorCBTRUS, 2000-2004

  15. Average Annual Age-Specific Rates for Malignant Behavior by Histology GroupingCBTRUS, 2000-2004

  16. Proportionate Distribution of Age-Specific Incidence Rates by Histology Grouping for Non-Malignant BehaviorCBTRUS, 2000-2004

  17. Average Annual Age-Specific Rates by Histology Grouping for Non-Malignant BehaviorCBTRUS, 2000-2004

  18. Top 5 Histology Groupings by Age GroupCBTRUS, 2000-2004 Rates are per 100,000 person-years.

  19. Brain and CNS Tumor Average Annual Age-Adjusted Incidence Rates and Trends for Behavior TypesSEER 17 Registries, 2004-2006 Rates are per 100,000 person years

  20. Brain and CNS TumorRelative Survival by Age GroupSEER, 1973-2006

  21. 5-Year Relative Survival by Era of DiagnosisSEER, 1975-2004

  22. Period Relative SurvivalSEER 17 Registries

  23. 5-Year Period Relative Survival forMalignant Tumors by GenderSEER, 1973-2006

  24. 5-Year Relative Survival by Race/Ethnic GroupSEER, 1973-2006

  25. 5-Year Relative Survival by Histology GroupingSEER, 1973-2006

  26. Summary Point • Brain and CNS tumors among adolescents and young adults are unique in that the patterns of site and histology groupings reflect transitional patterns from those observed for children to older adults.

  27. Summary Point Non-malignant tumors are an important subgroup in these age groups because of their high relative frequency compared with younger age groups.

  28. Summary Point Proportionately, non-malignant pituitary tumors exhibited high representation within these age groups.

  29. Summary Point Brain and CNS tumor incidence rates for Hispanics and Black, non-Hispanics were observed to be lower than their White, non-Hispanic and Other, non-Hispanic counterparts.

  30. Summary Point • 5-year period relative survival rates were observed to be greater than 60% in these age groups indicating improvements and progress in treatment outcomes.

  31. Acknowledgements This study was conducted under contract to CBTRUS which receives funding from the following sources: • American Brain Tumor Association • National Brain Tumor Society • Pediatric Brain Tumor Foundation • National Cancer Institute Contract #HHSN26100800766P

  32. The authors gratefully acknowledge the collaborators at state registries that provided data for this analysis: • Ms. Georgia Yee, Arizona Cancer Registry; • Ms. Randi Rycroft, Colorado Central Cancer Registry; • Ms. Cathryn Phillips, Connecticut Tumor Registry; • Ms. Betsy Cromartie, Delaware Cancer Registry; • Ms. Stacey Carson, Cancer Data Registry of Idaho; • Dr. Molly Schwenn, Maine Cancer Registry; • Dr. Susan Gershman, Massachusetts Cancer Registry; • Dr. Sally Bushhouse, Minnesota Cancer Surveillance System; • Ms. Debbi Lemons, Montana Central Tumor Registry; • Ms. Virginia Williams, New Mexico Tumor Registry; • Dr. Maria Schymura, New York State Cancer Registry; • Ms. Karen Knight, North Carolina Central Cancer Registry; • Dr. John Fulton, Rhode Island Cancer Registry; • Ms. Kay Dosch, South Dakota Cancer Registry; • Dr. Melanie Williams, Texas Cancer Registry; • Ms. Rosemary Dibble, Utah Cancer Registry; • Dr. Jim Martin, Virginia Cancer Registry; • Dr. Patricia Colsher, West Virginia Cancer Registry.

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