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神經傳導介質抑制類胜肽 （ Neurotransmitter-inhibiting peptides ）

神經傳導介質抑制類胜肽 （ Neurotransmitter-inhibiting peptides ）. acetyl-glutamyl-glutamyl-methyoxylglutaminyl-arginyl-arginylamide ( Argireline  ) 在細胞外藉由影響鈣離子調控的胞吐作用（ Calcium-dependent exocytosis ）所需的蛋白質生成，進而 抑制神經介質的釋放 。藉由 減少肌肉收縮而減少細紋和皺紋

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神經傳導介質抑制類胜肽 （ Neurotransmitter-inhibiting peptides ）

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  1. 神經傳導介質抑制類胜肽（Neurotransmitter-inhibiting peptides） • acetyl-glutamyl-glutamyl-methyoxylglutaminyl-arginyl-arginylamide (Argireline)在細胞外藉由影響鈣離子調控的胞吐作用（Calcium-dependent exocytosis）所需的蛋白質生成，進而抑制神經介質的釋放。藉由減少肌肉收縮而減少細紋和皺紋 • SNARE complex 是膜上蛋白質調控神經胞吐作用的核心，因為此一複合物會導致（Catecholamine）的釋放，如果Catecholamine釋放太多就會導致皺紋以及細紋的形成；所以此類的胜肽就是抑制SNARE complex 生成

  2. EGF : Epidermal Growth Factor表皮細胞生長因子 刺激老化皮膚細胞再活化 刺激表皮細胞生長 刺激其他活細胞激素分泌 刺激纖維母細胞分泌膠原蛋白及彈力蛋白 刺激受傷組織血管增生，加速癒合 傷口癒合過程中防止疤痕形成 抗皺 FGF: Fibroblast Growth Factor纖維母細胞生長因子 皮膚再生 刺激膠原蛋白及彈力蛋白合成 刺激纖維母細胞生長 刺激老化組織再生以及傷口癒合 刺激表皮細胞生長及移動 刺激毛髮生長，防止白頭髮形成 刺激玻尿酸合成 IGF: Insulin like Growth Factor類胰島素生長因子 扮演與生長荷爾蒙相同功能 刺激骨骼、肌肉及神經再生 刺激受傷組織血管增生 減緩腦下垂體老化 刺激玻尿酸合成 刺激毛髮生長並預防落髮 VEGF : Vascular Endothelial Growth Factor血管內皮細胞生長因子 血管內皮細胞生長因子是強力新血管生長因子 刺激血管細胞增生 刺激血管細胞移動 TGF-β3 : Transforming Growth Factor-β3 多功能的細胞激素 刺激細胞繁殖、生長及分化 去除疤痕的形成 協助傷口癒合 生長因子 Growth Factor

  3. 化粧品的奈米科技風潮 • 奈米結構易滲透至皮膚內層，讓化妝品的效果再也不侷限在單純的表面功夫 • 奈米載體可使其成分滲透至真皮層與角質層交界處，對需要深層吸收才得以發揮的美白、防皺與塑身等功能，可以得到更有效的發揮

  4. 化粧品與奈米科技 • 奈米化原料粒子 Nanoparticle • Titanium dioxide、Zinc oxide、Iron oxide • Mica and other metal oxide • 奈米容器載體 Nanocarrier • Liposome and ethosome • Nanosome and micelle • Fullerene • 奈米化纖維材料Nanofiber • Mask containing chitin/chitosan fiber

  5. HappiLindsay Elkins, Contributing Editor, December 2008 • Age gracefully? Not today’s consumer, who often seeks anti-aging advice from her dermatologist who, more often than ever these days, markets his or her own line of products. • Sales of professional skin care products rose 13% in 2007, with anti-aging products leading the category.

  6. The International Top 30 2008

  7. The International Top 30 2008

  8. 1. Unileverwww.unilever.com • Major Products: • Personal care—Axe/Lynx, Rexona/Sure and Degree deodorants; Dove, Caress, Lux and Lifebuoy soaps; Pond’s and Vaseline skin care products; Organics, Salon Selectives, SunSilk, Suave and ThermaSilk hair care products; Close-up and Signal oral care products. Household—Ala, All, Omo/Persil and Surf laundry detergents; Comfort and Snuggle fabric softeners; Sunlight dish detergent, Domestos bleach, Cif cleaners. • New Products: • Vaseline Cocoa Butter range, Clear anti-dandruff shampoo, Domestos Zero Limescale bleach.

  9. 2. L’Oréalwww.loreal.com • Major Products: • L’Oréal Paris, Garnier, Maybelline New York, SoftSheen Carson. • L’Oréal Professionnel, Kérastase, Redken, Matrix, Mizani, Pureology Luxury—Lancôme, Biotherm, Helena Rubinstein, Kiehl’s, Shu Uemura, Giorgio Armani, Parfums Cacharel, Ralph Lauren Fragrances, Paloma Picasso, Parfums Guy Laroche, Diesel, Victor & Rolf, Yue-Sai. Active Cosmetics—Vichy, La Roche-Posay, Skinceuticals, Sanoflore. L’Oréal’s operations also include The Body Shop and Galderma, and 50% stakes in Le Club des Créateurs de Beauté and Laboratoires Innéov. • New Products: • L’Oréal Professionnel Color Supreme, L’Oréal Professionnel Homme Cover 5 grey hair cover,  L’Oréal Paris Glam Shine, Derma Genesis/Skin Genesis, Lancôme Rénergie Morpholift Rare line, L’Oréal Professionnel Age Densiforce, La Roche-Posay Substiane anti-aging replenishing care, Maybelline Define-A-Lash, Lancôme Virtuose mascara, Shu Uemura Art of Hair, Mizani Butter Blend.

  10. 3. Henkelwww.henkel.com • Major Products: • Laundry and home care sold under brands such as Persil, Purex, Dixan, Vernal, Mir Colueurs, Pril, Bref, Spee Weißer, Riese and Somat. Cosmetics and toiletry brands include Schwarzkopf, Fa, Right Guard, Dial, Igora, Palette, Gliss, Kur, Schauma, Taft, Theramed and Diadermine. • New Products: • Laundry— Purex Natural Elements, Persil 20°C formulation; • Hair care— Palette Golden Gloss Browns, Gliss Kur Oil Nutritive, Schuama Kiwi Glanz, Taft Volume Power, Drei Wetter Taft Sensitive, BlondMe • Personal care— Fa Naturals shower gel and deodorant, Dial Yogurt; Skin care—Diadermine AgeExcellium • Oral care—Theramed 2-in-1 freshness, Theramed Titan Fresh.

  11. 4. Kaowww.kao.co.jp • Major Products:  • Household products, personal care products and color cosmetics. • New Products: • Sofina beauté, Sofina Primavista base makeup, Asience hair care (relaunched globally), Megurism steam eye mask, Attack Biogel liquid laundry detergent, Men’s Biore line (relaunched in Japan).

  12. 5. Reckitt Benckiserwww.reckittbenckiser.com • Major Products: • Surface care— Cillit Bang, Lysol, Dettol, Harpic. • Fabric care— Calgon, Vanish, Resolve, Spray ‘n Wash, Woolite. • Dishwashing— Finish, Electrasol • Home care– Airwik, Mortein • Health and Personal care— Veet, Dettols, Clearasil. • New Products: • Cillit Bang Grease & Floor, Dettol Herbal soap and shower gel, Veet Pump Pack, Mortein with Dettol, Mortein Naturgard range, Airwick Freshmatic Mini.

  13. 6. Beiersdorfwww.beiersdorf.com • Major Products: • Skin care, beauty care and toiletries sold under brand names that include Nivea, Eucerin, La Prairie, Slek, Labello, 8x4, Florena. • New Products: • Nivea Diamond Gloss hair products; Nivea My Silhouette  body shaping gel; Nivea for Men Extreme Comfort; Nivea For Men whitening oil control (India); Nivea for Men DNAge anti-wrinkle moisturizer; Nivea Good-Bye Cellulite dietary supplement capsules (U.S. only); Eucerin Hyaluron-Filler eye care.

  14. 7. Shiseidowww.shiseido.co.jp • Major Products: • Skin care, color cosmetics, sun care, fragrances, hair care and toiletries. Major brands include Shiseido, Carita, Decleor, IPSA, Ettusais, D’icila Parfums Issey Miyake, Parfums Jean Paul Gaultier, Parfums Narciso Rodriguez, Nars, Cle de Peau Beaute Za, Parfums Serge Lutens, Urara and Supreme Aupres. • New Products: • Clé de Peau Beauté La Crèmes, Revital, Aqua Label skin care, Acne& skin lightening series, Uno men’s skin care, Tsubaki Golden Repair hair care, Urara Makeup, Shiseido BOP intensive skin collective program, Shiseido Zen fragrance (relaunch).

  15. 8. LVMHwww.lvmh.com • Major Products: • Fragrances and cosmetic sold under brands such as Christian Dior, Guerlain, Givenchy, Kenzo, Acqua di Parma, Parfums Loewe, Benefit, Fresh and Makeup Forever. LVMH also owns Sephora, the beauty products retailer. • New Products: • Dior— Fahrenheit 32 for men, Midnight Poison Addict Shine fragrances, Capture L’ Ore de Vie, Diorskin foundation, Backstage. • Guerlain— L’Instant Magic, Eau de Shalimar, Aqua Allegoria Figue Iris and Aqua Allegoria  Laurier Réglisse,  Cruel Gardénia, Cherry Blossom delight, My Insolence. • Parfums Givenchy— Organza Jasmin 2007, Very Irresistible Rosa Damascena 2007, Amarige Mimosa 2007, Vetyver, Rouge Interdit lipstick. • Parfums Kenzo— Tokyo by Kenzo for men, Vintage Edition. • Benefit— Love Your Look, That Gal face brightening primer. • Makeup Forever— Aqua Eyes waterproof eyeliners. • Acqua de Parma— Colonia Intensa. • Parfums Loewe— Quizas, Quizas Quizas. Fendi Palazzo and Pucci Vivara fragrances.

  16. 9. Lionwww.lion.co.jp • Major Products: • Oral care (toothpastes, toothbrushes mouthwashes, breath fresheners, dental needs); beauty care (shampoos, conditioners, treatments, hair styling products, men’s hair care, soap, body washes, skin care, antiperspirants and deodorants); fabric care (laundry detergents and additives, bleaches, fabric softeners); home care (dishwashing detergents, disinfectants, household cleaners, kitchen-related products) and insecticides. • New Products: • Household— Soflan with Fragrance and Deodorant fabric softener, Top Kaori Tsuzuku chamomile-scented liquid laundry detergent with fabric softener, Look O2 Cleaner (joint product with Henkel), Charmy gel-based dishwasher cleaner/detergent. • Oral care— Dentor Systema EX Extra Herb, Medish oral care gum. • Personal care— Ban Deodorant Mist, Ban Refresh Powder Sheets, Bathology skin care, Pro Tec Head men’s hair care.

  17. 10. Chanelwww.chanel.com • Major Products: • Skin care, color cosmetics and fine fragrances. • New Products: • Skin care— Sublimage Essential Regenerating Cream, Hydramax + Active moisture tinted lotion SPF 15 • Color cosmetics— Facettes d’or nail color; Robertson Boulevard limited edition nail collection • Fragrance— Allure pour Homme Edition Blanche,  Chance Eau Fraîche, Allure Homme Sport Cologne Sport, No. 5 Eau Première.

  18. 11. Yves Rocherwww.yvesrocher.com • Major Products: • Skin care, cosmetics and fine fragrances marketed under the brand names of Yves Rocher, Daniel Jouvance, Dr. Pierre Ricaud and Kiotis. • New Products: • Fragrance— Naturelle, Comme une évidence Homme. • Personal care— Plaisirs Nature Kiwi eau de toilette and shower gel • Skin care— Culture Bio.

  19. 12. Naturawww.natura.net • Major Products: • Natura Ekos, Natura Tododia, Natura Chronos, Natura Mamãe e Bebê, Natura Diversa, Natura Amor América. • New Products: • Natura Amor América, Natura Naturé, Natura Tododia, Natura Diversa Hidratação Prolongada, Natura Chronos Politensor de Soja, Natura Aguas, Natura Fixplant, Natura Faces, Natura Mamãe e Bebe, Natura Ekos Cacau, Natura Homem Chromo, Natura Erva Doce Hidratante Facial, Natura Crer Para Ver Bolsa Amiga do Meio Ambiente.

  20. 13. GlaxoSmithKlinewww.gsk.com • Major Products: • Toothpaste and mouthwash— Aquafresh, Dr. Best, Macleans, Odol, Odol Med 2, Polident, Polygrip, Sensodyne • Denture care— Polident, Polygrip, Corega. • New Products: • Aquafresh iso-active foaming gel

  21. 14. AmorePacificwww.amorepacific.co.kr • Major Products: • Skin care and makeup— Laneige, Iope, Mamonde, Innisfree, Hera, Lirikos. • Fragrances— Lolita, Lempika, Castel Bajac, Espoir. • New Products: • Sulwhasoo su Essence, ioPE Whitegen RXC, V=B Yeginseng, premium makeup from Laneige, Happy Bath Blue Spa Essential Body Cleanser.

  22. 15. Koséwww.kose.co.jp • Major Products: • Skin care, cosmetics and toiletries. • New Products: • Junkisui skin care.

  23. 16. Clarinswww.clarins.com • Major Products: • Skin care, fine fragrance, color cosmetics and sun care sold under brand names such as Clarins, Thierry Mugler, Azzaro, Stella Cadente and My Blend. • New Products: • My Blend customizable skin care

  24. 17. Oriflamewww.oriflame.com • Major Products: • Skin care, fragrances, color cosmetics, toiletries and accessories. • New Products: • Enigma and Radiant Lights fragrances, Optimals Radiance Glow self tanner, Lift Expert, Perfect Body, Lash Extreme, Royal Velvet Intensive Revitalizing Cloth Mask. Also, Diamond Musk, Silky Kiss lipstick, Diamond Cellular Anti-aging cream and Dermoprofessional Bio-Peeling Kit (all in September).

  25. 18. LG Household & Healthcarewww.lgcare.com • Major Products: • Household— laundry and dishwasher detergent, fabric softener, kitchen cleaners. • Personal care— toothpaste, shampoo, soap, baby care, skin care, color cosmetics and toiletries. • New Products: • su:m 37 fermented cosmetics, Borrowing Earth household products.

  26. 19. Puigwww.puig.com • Major Products: • Fragrances— Adolofo Dominguez, Agatha Ruíz de la Prada, Ague Brava, Anouk, Antonio Banderas, Barbie, Carmen Sevilla, Don Algodon, Maja, Mango, Massimo Dutti, Pachá, Quorom, Roasiro Flores, Sportman, Victori & Lucchino, Zara, Boston Man, 1916, Antonio Miro, Azur de Puig, Brummel, Eau d’Ete, Equinox, Farala, Springfield, Yacht Man Blue, Zinnia. • Personal Care— Payot, Dennenes, Heno de Pravia, Lactovit, Vitese,   Kinesia, Maja, Agua Lavanda Puig, Maderas, Misslyn, Nelia, VF. • New Products: • Blue Seduction for Women

  27. 20. Pierre Fabrewww.pierre-fabre.com • Major Products: • Skin care and hair care products sold under the Avéne, Ducray, Pierre Fabric Dermatologie, Klorane, Galénic and Réne Furterer banners. • Comments: • Pierre Fabre’s Dermo-Cosmetics unit earmarks 5% of its sales for research projects, which are conducted at its centers in Vigoulet-Auzil and Saint-Jacques Hospital in Toulouse. Research conducted in Toulouse is made possible through an  agreement between the Pierre Fabre group, the local university hospital and Toulouse University.

  28. 21. YSL Beautéwww.guccigroup.com • Major Brands: • Fragrances, cosmetics and skin care products. Brands include Yves Saint Laurent, Roger & Gallet, Stella McCartney, Alexander McQueen, Boucheron and Ermenegildo Zegna. • New Products • Fragrance— Yves Saint Laurent Elle, Paris Nuit de Fete, Paris Pont des Amours, Opium Poesie de Chine Eaux d’Orient, L’Homme Yves Saint Laurent Eau d’Été 2008, Elle Yves Saint Laurent summer fragrance 2008, Cinéma Scénario d’été, Baby Doll Magic; Ermenegildo Zegna Z Zegna Fresh; Stella McCartney Stella Sheer 2008. • Cosmetics—LipTwins.

  29. 22. Polawww.pola.co.jp • Major Products:  • Skin Care— Alvita, Whitissimo, Day + Day Vitax, Botanex, 1/f, Plenna, Polissima, BA, Signs Solution 28 Carats, Signs Solution Wrinkle Shot, Evangile • Cosmetics— Whitissimo, Silfique, Vivoke, Aniak, Maquifard, Super Suncare, Southern Call • Body Care— Feel & Heal; Hair Care—Idea Style, Simfree Hair Color • Men’s Care— Galantom, GR Shot S. • New Products: • Whitissimo base makeup.

  30. 23. PZ Cussonswww.cussons.com • Major Products: • Personal care products sold under brands including Imperial Leather, Joy, Cussons Kids, Premier, Carex, Baby, Luksja, Makler, Sweet Seventeen, Venus Hair, Original Source. Household product brands including Morning Fresh, Elephant, E, Radiant, Robb, Duck and Minerva. • New Products: • Imperial Leather SkinBliss.

  31. 24. The Bolton Groupwww.boltongroup.net • Major Products: • Laundry care products—Omino Bianco, Merito, Nibro • Bathroom/kitchen care and cleaners—WC Net,  Fornet, Last,  Dubro, Solivaisselle • Surface & Floor Care—Carolin, SMAC, Overlay,  Vetril, WC Eend • Household soap products—Cyclon, D’orn. Personal Care—Neutro Roberts, Borotalco, Rogé Cavaillès, Sanogyl, Somatoline,  Roberts Fragrance, Acque Alle Rose Robert, Citrosil, Botot, Wetties, Soapy, Silx • Beauty—Collistar skin care, makeup, hair care. • New Products: • Collistar—Long Lasting Color Line and Nourishment and Lustre Lines for hair care, Body Energizing Treatment for men, Global Anti-Age Protection Tanning Face Cream SPF 30-50+, Supertanning Moisturizing Dry Oil SPF 15, Sun Effect Make-Up line, Topgloss Stick Reflex, Magnifica Patch-Lifting-Dermal Filling Repairing Face and Neck Mask, Perfecta Active Neck and Décolleté Cream, Magic Drops self-tanning concentrate, Brightening Touch highlighting concealer, Eye Contour Lifting Treatment for men, Perfect Adherence Shaving Foam, Moisturizing Soothing Sensitive Skins, Perfect Adherence Shaving Foam, Moisturizing Softening Tough Beards, Extreme Supermascara, Anti-Time 360° for Men. Rogé Cavaillès—Dermatological Deo-Care deodorant.

  32. 25. Sunstarwww.jp.sunstar.com • Major Products: • Oral care and beauty care products.

  33. 26. The Colomer Groupwww.thecolomergroup.com • Major Products: • Hair and nail care products. • Professional— Revlon Professional, Intercosmo, Modern Organic Products, American Crew, D:FI, Creative Nail, Tigi • Consumer— Fermodyl, Fixpray, Floïd, Geniol, Lanofil, Llongueras, Natural Honey, Revlon Flex, ZP11 • Cosmetics— BioPoint, Burberry (license), Gatineau (license), Revlon (license); St DuPont (license), Ultima II (license) • Multicultural— African Pride, Arosci, Creme of Nature, Fabu-Laxor, Revlon Realistics, Special Feeling. • New Products: • Crème of Nature—Red Clover and Aloe Daily Breakage Relief and Jojoba & Olive Oil Moisture Active Deep Conditioning treatment; African Pride—Miracle Deep Conditioning No Lye Relaxer System with Healing & Hydrating African Herbs.

  34. 27. Mandomwww.mandom.co.jp • Major Products: • Men’s toiletries—Gatsby and Lucido and Women’s toiletries—Lucido L, Produce, Pixy and Simplity.

  35. 28. Lornamead Groupwww.lornamead.com • Major Products: • Hair care— Aqua Net, Finesse, Harmony, Lypsyl, Vosene. • Cosmetics and skin care— CD, Handsan, Tura. Fragrance and bath—Woods of Windsor, Yardley. • Oral Care– Brilliant, Rapid White. • New Products: • Vosene new shampoo range, Finesse revitalizing shampoo, LypSyl Beeswax lip balm.

  36. 29. Menardwww.menard.co.jp • Major Products: • Skin care, cosmetics and fragrances.

  37. 30. Fanclwww.fancl.co.jp • Major Products: • Cosmetics and skin care products sold under the Attenir, Fancl and Nicostar banners. • New Products: • Fancl Sunguard SPF 30.

  38. Thank you !

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