Rate-Determining Steps Revisited SN2 SN1 E2 E1
Leaving Group Ability and SN2/SN1/E2/E1 Reactions • SN1 reactions are more sensitive to leaving group ability than SN2 reactions are. • Excellent leaving groups favor SN1 and E1 reactions over corresponding SN2 and E2 reactions.
Hyperconjugation secondary can do 2x, tertiary can do 3x
polar solvents especially good for SN1 (OK for some SN2) aprotic solvents (no H on O or N) cannot H-bond to Nu especially good for SN2
Inter- vs Intra- molecular Reaction forms ring