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CHM 3240 – Biochemistry

CHM 3240 – Biochemistry Instructor - Paul Stein S3305 phone = 6065 email = pstein@css.edu Meeting Times - MWF 9:15 - 10:20 - S2316 Office Hours: MWF 12:30 – 1:45, T 11:00 – 12:00, R 1:00 – 2:00 Please feel free to make an appointment or drop in at any time.

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CHM 3240 – Biochemistry

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  1. CHM 3240 – Biochemistry Instructor - Paul Stein S3305 phone = 6065 email = pstein@css.edu Meeting Times- MWF 9:15 - 10:20 - S2316 Office Hours: MWF 12:30 – 1:45, T 11:00 – 12:00, R 1:00 – 2:00 Please feel free to make an appointment or drop in at any time. Title: Lehninger Principles of Biochemistry Author: Nelson and CoxISBN: 1429234148 Required How many of you have iClickers? General Education - Fine Arts – and Biochemistry

  2. Draw structural formulas for the following: draw all bonds except those to H atoms. e.g. Ethanol = CH3 – CH2 - OH methylamine acetic acid Acetaldehyde or ethanal acetone (dimethylketone) An ester formed from two compounds above An amide formed from two compounds above

  3. Macromolecules Carbohydrate ― polyhydroxyaldehydes and ketones sugars: monosaccharides & disaccharides e.g. glucose, fructose, sucrose, lactose polysaccharides: e.g. starch, glycogen, cellulose Lipids ― soluble in nonpolar solvents fatty acid esters ― steroids ― prostaglandins ― leukotrienes Protein ― functionalpolymers of amino acids enzymes ― transporters/receptors ― immunoglobulins etc. Nucleic Acid ― polymers of nucleotides DNA – genetic material that encodes information for cell’s proteins RNA- conversion of DNA information into protein may also function as regulators of gene expression & catalysts

  4. Macromolecule Functions Structure ― Make up the substance used to construct cells and the extracellular matrix of organs Energy ― Serves as the fuel for cellular metabolism Digestion of macromolecules followed by the oxidation of the molecular units of macromolecules provides cellular energy. Communication ― molecules inform and direct the regulation of cellular processes. Examples include: nerve transmission, regulation of gene expression, regulation of metabolism, cell-cell interactions etc.

  5. Macromolecule Functions Energy ― Serves as the fuel for cellular metabolism Nutrition Labels Total Fat - saturated - trans - cholesterol Total Carbohydrate ― starch and sugars dietary fibers ― mostly cellulose (undigestible) Protein Na, Ca, Fe, Vitamins A & C

  6. Good Bad Indifferent saturated fat trans fat cholesterol sugars fiber Na Ca Fe Vit. A Vit. C

  7. Nutrition Labels – peanut butter Serving size: 2Tbs (32g) (35 servings per container) Calories 190: calories from fat 130 Total fat 16g (25%) saturated fat 3g (16%) trans fat 0g cholesterol 0mg (0%) Calories Fat ~ 9 Cal/g Carbohydrate & Protein ~ 4 Cal/g Sodium 110mg (5%) Total carbohydrate 7g (2%) dietary fiber 2g (12%) sugars 3g Protein 7g (3%) vitamin A 0% vitamin C 0% calcium 0% iron 4%

  8. wt in kg ht2 in cm2  10,000 Body Mass Index - BMI wt in lbs ht2 in in2  730 1 kg = 2.23 lbs. & 1 in = 2.54 cm underweight < 18.5 normal 18.5 – 24.9 overweight 25.0 – 29.9 obese > 30.0 Basal metabolic rate (BMR) Men = 66 + 13.7  wt (kg) + 5  ht (cm) – 6.6  age (yrs) Women = 655 + 9.6  wt (kg) + 1.8  ht (cm) – 4.7  age (yrs) add 30% for ordinary activity add 50% for regular exercise

  9. Structure PROTEINS Polymers of Amino Acids DNA (gene) mRNA Protein sequence YMGCFTSSGLIVVEHY... Function

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