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The Immune Response to Tumors

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The Immune Response to Tumors

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    1. The Immune Response to Tumors MCDB 4300 Rachel McMahan

    6. Evidence for immune surveillance Inflammatory responses (lymphocytes, macrophages, NK cells) around and within solid tumors Tumor reactive T cells can be isolated from tumor bearing animals and human patients

    14. Cancer Immunoediting Elimination Initiation of the antitumor immune response by cells of the innate immune system (macrophages, NK cells). Antigens are liberated and the adaptive response is activated. T cells infiltrate. Equilibrium Escape

    15. Cancer Immunoediting Elimination Equilibrium Lymphocytes infiltrate tumor, but do not fully extinguish it. Small numbers of tumor cells remain Can last up to 20 years. Escape

    17. Cancer Immunoediting Elimination Equilibrium Escape Tumors have high genomic instability. Tumors select for mutations that allow for evasion of the immune response.

    19. Experimental immunotherapy for cancer Non-specific approaches Polyclonal activation with cytokines Introduction of co-stimulatory molecules or cytokines into tumor Antigen-specific approaches Tumor-specific antibodies Vaccination with tumor antigens Administration of expanded tumor-specific T cells back into patients.

    23. Vaccination with tumor antigens

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