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Facts. Over 200 blood antigens exist!Unfortunately, we only get to review the most relevant antigensWe will discuss each of these major antigens, their antibodies, and the clinical significance of each. Major Blood Group Systems. LewisI P MNSs KellKiddDuffy. Basic terms to remember. Clinical significance: antibodies that are associated with decreased RBC survivalTransfusion reactionsHDN Not clinically significant: antibodies that do not cause red cell destructionCold reacting anti9460

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