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Understanding the PATCHED Gene: Role in Cell Fate and Cancer

Discover the crucial role of the PATCHED (Ptc) gene in controlling cell fate by inhibiting Hedgehog (Hh) signaling. Learn how Ptc regulates cell cycle and impacts cancer development, including Gorlin Syndrome and various carcinomas. Explore its significance in neural development and potential therapeutic implications.

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Understanding the PATCHED Gene: Role in Cell Fate and Cancer

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  1. The PATCHED (Ptc) Gene Brendan McQuellon

  2. What is PATCH • Transmembrane surface receptor • Binds ligands of Hedgehog(Hh) family Weinberg, 2007

  3. Normal Ptc Role • Controls cell fate by inhibiting Hh/Shh signaling • Inhibits the transcription of Hh/Shh target genes • Can regulate the cell cycle

  4. Shh/Ptc/Gli pathway http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg Weinberg, 2007

  5. Shh/Ptc/Gli pathway http://www.armchairempire.com/images/feature-articles/Weekly-Top-10/pub-crawl/sonic-hedgehog.jpg Weinberg, 2007

  6. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  7. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  8. Sonic hedgehog and Patched regulate neural development http://scienceblogs.com/pharyngula/2007/03/basics_neurulation.php www.pressthebuttons.com/

  9. Sonic hedgehog and Patched regulate neural development Goodrich et al, 2007 www.pressthebuttons.com/

  10. How KO’s were made Goodrich et al., 1997

  11. Heterozygous Mice Goodrich et at., 1997

  12. Heterozygous Mice Goodrich et at., 1997

  13. How does Ptc relate to cancer? • Gorlin Syndrome • Basal Cell Carcinomas • Medulloblastomas • Sporadic Instances • Ionizing Radiation http://www.medicalecology.org/images/atmosphere/skincancer1.gif

  14. How does Ptc relate to cancer? • Meningiomas, Breast and Esophageal carcinomas • Shh/Ptc pathway hyperactive in many other cancers

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