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Advanced Imaging Protocols for Spinal Cord Injury Research Team

Explore biomarkers for predicting functional recovery using advanced imaging techniques such as multi-parametric MRI with myelin-specific sequences, higher spatial resolution, functional MRI, and H-response physiological correlates. Investigate brain fMRI correlations with electrophysiological methods for nociceptive reflex. Discuss metrics matching clinical scores and understanding biophysical properties. Consider imaging requirements, inclusion criteria, and multi-centric study protocols for SCI patients. Align imaging protocols in Quebec City.

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Advanced Imaging Protocols for Spinal Cord Injury Research Team

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  1. Perspectives for ERRSM team Clinical protocol • Provide biomarkers that predict functional recovery • Multi-parametric MRI (DTI, MTR, atrophy, T2*-w) Research protocol • Other myelin-specific sequences • Higher spatial resolution  Isolate spinal pathways • Functional MRI • Physiological correlates of the H response (Doyon) • Brain fMRI correlates with combined electrophysiological methods of • the nociceptive flexion (RIII) reflex (Rainville) Julien Cohen-Adad

  2. Discussion Correlations • What metric with what clinical/electrophy score? • Understand biophysical properties of MRI metrics and • neuropathology (ex vivo validation?) Practical considerations • Requirements for imaging SCI patients (equipments, …) • Inclusion criteria (level of injury, implants, …) • Multi-centric study (match imaging protocol) Julien Cohen-Adad

  3. TODO Matching protocol in Quebec City • Rick & Julien iront à Québec fin juin pour s’assurer que le protocole d’imagerie est similaire à celui de l’UNF Julien Cohen-Adad

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