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DISORDER OF SKIN APPENDAGES. TOPICS INCLUDED. Acne vulgaris Rosacea Miliaria Excessive hair loss Excessive hair growth. DISORDER OF SENACEOUS GLANDS Acne vulgaris. Sebaceous glands. Develop embryologically from hair germs, but a few free glands arise from the epidermis.

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topics included
TOPICS INCLUDED
  • Acne vulgaris
  • Rosacea
  • Miliaria
  • Excessive hair loss
  • Excessive hair growth
sebaceous glands
Sebaceous glands

Develop embryologically from hair germs, but a few free glands arise from the epidermis.

The glands themselves are multilobed

Contain cells full of lipid(sebum), which are secreted (holocrine secretion-when whole cell is secreted into the lumen)

slide5

Sebum is discharged into the upper part of the hair follicle.

It lubricates and waterproofs the

skin, and protects it from drying;

It is also mildly bactericidal and fungistatic.

slide6

ACTIVITY

Androgenic hormones, especially dihydrotestosterone, stimulate sebaceous gland activity.

Human sebaceous glands contain 5α-reductase, 3α- and 17α- hydroxysteroid dehydrogenase

Convert weaker androgens to dihydrotestosterone, which in turn binds to specific receptors in sebaceous glands, increasing sebum secretion.

So , not the levels of circulating androgens but an enhanced target organ sensitivity which is important.

slide7
Acne

Acne is a disorder of the pilosebaceous apparatus predominantly affecting the peripubertal popln andcharacterized by comedones, papules, pustules, cysts and scars.

prevalence
Prevalence

Nearly all teenagers have some acne (acne vulgaris).

It affects the sexes equally, starting usually between the ages of 12 and 14 years, tending to be earlier in females.

The peak age for severity in females is 16–17 and in males 17–19 years.

Variants of acne are much less common.

causes of acne vulgaris
Causes of Acne vulgaris

Many factors combine to cause acne characterized by chronic inflammation around pilosebaceous follicles

sebum
Sebum

Sebum excretion is elevated.

hormonal changes
Hormonal changes
  • Androgens (from the testes, ovaries,adrenals and sebaceous glands themselves) are the main stimulants of sebum excretion,
  • In most of the cases the level of the androgens are within normal limit but there is enhanced end organ sensitivity (incred.activity of enzyme 5-alpha reductase)
  • Other hormones (e.g. thyroid hormones and growth hormone) have minor effects too.
poral occlusion
Poral occlusion

Occluded by keratinous plug induced by:

  • Both genetic and environmental factors (e.g. some cosmetics)
  • Reduced levels of linoleic acid in sebaceous gland secetions of acne patient
  • Results in vicious cycle of retentin of sebum to growth of microbs. Distention of follicle eventually ruptures releasing pro-inflammatory chemicals into dermis stimulating intense inflammation.Theductal epithelium also produces cytokines and an inflammatory cascade is triggered.
bacterial propionibacterium acnes
Bacterial Propionibacterium acnes

Acts as a source of antigenic stimulation,triggering a type IV inflammatory response.

Produce extracellular enzymes which attract inflammatoy cells.

factors modifying acne
Factors modifying Acne

Genetic predisposition(mode of inheritence not clear)

The condition is familial mostly with severe cystic acne

Identical twins

Cosmetics

Menstrual cycle

Psychological factors- anger, anxiety

presentation
Presentation

Polymorphic eruption:

papules,pustule,comedones,nodules and cysts

Lesion heals with depressed or hypertrophic scarring and

Post-inflammatory hyperpigmentation can

follow.

slide17

Lesions are confined to the face, shoulders, upper chest and back.

Open comedones (blackheads), because of the plugging by keratin and sebum of the pilosebaceous orifice on the skin surface, or

Closed comedones (whiteheads), caused by plugging below the skin surface.

Associations :

Most have a background of greasy skin(seborrhea) with patulous follicular openings(pores)

slide18

Acne associated with virilization

May be caused by an androgen-secreting tumour of the adrenals, ovaries or testes or, rarely,

congenital adrenal hyperplasia

Acne accompanying the polycystic ovarian syndrome is caused by modestly raised circulating androgen levels

variants of acne
Variants of acne
  • Infantile acne may follow transplacental stimulation of a child’s sebaceous glands by maternal androgens.
  • May present at birth or may last for upto 3yrs
  • Its morphology is like that of common acne and it may be the forerunner of severe acne in adolescence.
slide20

Papulopustular lesions in an odd distribution.

The patient played the violin (‘fiddler’s neck’)

Mechanical.

Excessive scrubbing, picking, or the rubbing of chin can rupture occluded follicles.

drug induced
Drug-induced

Steroid-induced acne in a seriously ill patient.

  • Lesions are monomorphic and esp. over back ,face may be involved
  • Suspicion should be raised when acne, dominated by papulopustules rather than comedones appear suddenly in a nonteenager
  • And coincides with the prescription of a drug known to cause acneiform lesions
  • Corticosteroids
  • Androgenic
  • Anabolic steroids
  • Gonadotrophins
  • Oral contraceptives
  • Lithium, iodides, bromides, antituberculosis and anticonvulsant therapy can all cause an acneiform rash.
acne due to cosmetics
Acne due to cosmetics

Cosmetics esp. oil based or other topical preparations may induce comedone formation or precipitate inflammation around hair follicles.

slide23

Conglobates (gathered into balls) is the name given to a severe form of acne with all of the above features as well as abscesses or cysts with intercommunicating sinuses that contain thick serosanguinous fluid or pus.

On resolution, it leaves deeply pitted or hypertrophic

scars, sometimes joined by keloidal bridges.

Hyperpigmentation is usually transient, it can persist, particularly in those with an already dark skin.

fulminans acne fulminans
Fulminans Acne fulminans

It is a rare variant in which conglobate acne with ulcerated and crusted lesion and is accompanied by

Fever, arthralgia,myalsia and a high erythrocyte sedimentation rate (ESR).

slide25

chloracne

Exogenous Tars, chlorinated hydrocarbons, oils and oily cosmetics can cause or exacerbate acne.

Suspicion should be raised if the distribution is odd(forearm, legs)or unusal age(mid age male) or if comedones predominate

excoriated
Excoriated

This is most common in young girls.

Obsessional picking otherwise mild acne

Results in excoriations on face while primary lesions not visible

late onset
Late onset

This too occurs mainly in women

Is limited to the chin.

Nodular and cystic lesions are predominant.

It is stubborn and persistent.

tropical
Tropical

This occurs mainly on the trunk and may

be conglobate.

acne after facial massage
Acne after facial massage
  • Acne following (3-6 wks later) in abt 30% of patients
  • Nodules with few comedones
  • Along mandibular region
course
Course

Acne vulgaris clears by the age of 23–25 years in 90% of patients,

Some (5% of women and 1% of men) still need treatment in their thirties or even forties.

investigations
Investigations

None are usually necessary.

Cultures are occasionally needed to exclude a pyogenic infection, an anaerobic infection or Gram-negative folliculitis.

slide32

Any acne, including infantile acne, that is associated with virilization needs investigation to

    • Exclude an androgen-secreting tumour of the adrenals, ovaries or testes
    • To rule out congenital adrenal hyperplasia
differential diagnosis
Differential diagnosis

Rosacea affects older individuals

Pyogenic folliculitis

Hidradenitis suppurativa is associated with acne conglobata, but attacks the axillae and groin.

Pseudofolliculitis barbae, caused by ingrowing hairs, occurs on the necks of men with curly facial hair and clears up if shaving is stopped.

treatment
Treatment

General measures

Acne frequently has marked psychological effects.

Even those with mild acne need sympathy, optimistic approach is essential, and regular encouragement is worthwhile.

Local hygiene, diet, stress

local treatment
Local treatment
  • 1 Regular gentle cleansing with mild soap and water
  • Benzoyl peroxide.
    • This antibacterial agent plus decreases inflammation
    • applied only at night initially, but can be used twice daily if this does not cause too much dryness and irritation.
  • Retinoic Acid(RA)/tretinoin
    • The vitamin A (retinol) analogues (tretinoin, isotretinoin, adapalene,(recently introducedand less irritent) ,tazarotene)normalize follicular keratinization, and reduce sebum production and reduce inflammation,decrease p.acne
  • They are especially effective against comedones.
  • Patients should be warned about skin irritation (start with small amounts) and photosensitivity.
slide36

The weakest preparation should be used first, and applied overnight on alternate nights.

Sometimes, after a week or two, it will have to be stopped temporarily because of irritation.

The combination of benzoyl peroxide in the morning and tretinoin at night has many advocates.

Isotretinoin 0.05%, 0.025%, 0.1%

Other agents

Azelaic acid :reduce post acne hyperpigmentation

Alpha hydroxy acids eg. Glycolic acid

topical antibiotics
Topical antibiotics

Topical clindamycin, erythromycin and sulfacetamide

Cosmetic camouflage- Cover-ups help some patients, especially females, whose scarring is unsightly. They also obscure post-inflammatory pigmentation.

systemic treatment
Systemic treatment

Antibiotics

  • tetracycline includes:doxycycline and minocycline mostly used and less frequently erythromycin and azithromycin
  • Used in mod. to severe acne and in those who are having psy. problem
  • Tetracycline-1gm,doxycycline-100mg,minocycline-100mg, erythromycin-1gm, azithromycin-250mg daily for long periods of time up to 6 mths or even longer.
  • It should be taken on an empty stomach, 1 h before meals or 4 h after food
slide39

Oral antibiotics should be combined with topical agents because then it is possible to withdraw the antibiotic and maintain in topical therapy.

  • Side effects:
  • GI disturbance
  • Vaginal candidiasis
  • Resistance
  • Grayish pigmentation in case of minocycline
  • To be avoided in pregnancy.
hormonal
Hormonal
  • Antiandrogenics only for females
  • Cyproterone acetate, a combined antiandrogen–oestrogen treatment
  • Combined oral contraceptives
  • Spironolactone
  • Isotretinoin- for severe intractable acne
  • Severe acne,conglobata
  • Relapses
  • Side effects:dryness of skin, eye,nosebleed,initial aggravation of inflammation , myalsia, altered night vision and hair loss, avoided in pregnancy,
  • Careful monitoring with blood pictures and pregnancy test before and after starting rx
acne scar treatment
Acne scar treatment
  • Dermabrasion This helps to smooth out facial scars.
  • Lasers Skin resurfacing with CO2 and erbium lasers is rapidly replacing dermabrasion and chemical peeling
  • Dermal fillers Bovine collagen or hyaluronic acid fillers can be injected into depressed scars to improve their appearance.
  • Cryotherapy
  • Intralesionalcorticosterois
definition
definition

Rosacea is a chronic skin disorder characterized by erythema and telangiectasia and punctuated by acute episodic eruption of papules, pustules and swelling.

slide44

Rosacea affects the face of

adults, usually women.

  • Although its peak incidence is in the thirties and forties, it can also be seen in the young or old.
  • It may coexist with acne.
cause
cause
  • Rosacea is often seen in those who flush easily in response to warmth, spicy food, alcohol or embarrassment.
  • Hereditary component
  • Fair-skinned
  • Psychological abnormalities
  • chemicals, high dosages of isotretinoin, benzoyl peroxide and tretinoin.
  • A pathogenic role for the follicular mite dermodexfolliculorum as well as for microaerophilic gm negetive bacterium. Helicobacter pylori is suspected but has not been confirmed.
sites
sites
  • The cheeks, nose, centre of

forehead and chin are most commonly affected

  • The periorbital and perioral areas are usually spared
  • Lymphoedema, below the eyes and on the forehead, is seen in few cases
  • Intermittent flushing is followed by a fixed erythema and telangiectases.
  • Discrete domed inflamed papules, papulopustules and, rarely, plaques or nodules develop
  • No comedones or seborrhoea
slide47

Usually symmetrical

Exacerbations and remissions

types
types

1. Papulopustular rosacea

  • Inflammatory lesions are predominant
  • Some permanent redness with red papules with some pus filled pustules (typically last 1-4 days); this subtype can be easily confused with acne.
types49
Types..

2. Erythematotelangiectatic rosacea

  • Vascular features predominate
  • Permanent redness / erythema with a tendency to flush and blush easily.
  • Small blood vessels are usually visible near the surface of the skin k/a telangiectases, sometimes associated with burning or itching sensations.
types50
Types…

3. Phymatous type

  • This subtype is most commonly associated with rhinophyma, an enlargement of the nose.
  • Symptoms include thickening of skin, irregular surface, nodularities, and enlargement of nose.
  • Phymatousrosacea can also affect chin (gnatophyma), forehead (metophyma), eyelids (blepharophyma), and ears (otophyma).
  • Small blood vessels may be visible near the surface of the skin (telangiectases).

.

types51
types

4. Ocular type

  • Red, dry and irritated eyes and eyelids. Some other symptoms include foreign body sensations, itching and burning
complications
Complications

Rhinophyma

Blepharitis

Conjunctivitis

Keratitis

lymphedema

rhinophyma
Rhinophyma

Hyperplasia of the sebaceous glands and connective tissue of the nose

Common in males

differential diagnosis54
Differential diagnosis

Acne

Seborrhoeic eczema

Perioral dermatitis

Systemic lupus erythematosus

Photodermatitis

Menopausal symptoms

Superior venacaval obstruction

treatment56
Treatment

Topical agents

  • Topical metronidazole (0.75% metronidazole gel)
  • Retinoic acids
  • Corticosteroids not to be used
  • Systemic therapy:
  • Antibiotics- tetracyclines-start with 1 gm a day reduce dose to 250mg daily over a period of 2-3 ,months ,as the lesions respond
  • Erythromycin second choice
  • Metronidazole
  • Isotretinoin 1mg/kg body weight daily for 3-6mths
slide57

Various techniques can be used to improve the appearance of disfiguring rhinophymas

    • Surgical excision
    • Cryotherapy
    • Electrocautery
    • Argon or CO2 laser ablation.