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IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...nature

Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function. IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...www.nature.com. Inflammation in IR. Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis

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IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...nature

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  1. Simplistic Inflammatory and Non-Inflammatory Effects of Insulin Resistance on B-Cell Function IAPP boosts islet macrophage IL-1 in type 2 diabetes : Nature ...www.nature.com

  2. Inflammation in IR

  3. Pathogenesis and biological interventions in T1DM- LIKE autoimmune diabetes- Insulitis The class I MHC molecules are hyperexpressed on the β-cell surface in T1D patients making β-cells more susceptible to cytotoxic lymphocyte (CTL)-mediated destruction. Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease http://dx.doi.org/10.1016/j.clim.2014.11.007 Clinical Immunology, 2014 Juha Grönholm , Michael J. Lenardo

  4. Treatment IR induced Inflammation

  5. Implications for Therapy • Treat Central Mechanisms IR • Treat Peripheral IR- fat, liver, muscle • Treat Inflammation • Treat Biome

  6. Metabolic Derangement, and Insulin Resistance Associated with Microbiome Lipopolysaccharides LPS Fasting-induced adipocyte factor Pioglitazone Treats Secondary Adverse Effects of Abnormal Biome

  7. Probiotic, Prebiotic and Antibiotic Treatment of Abnormal Gut Biome

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