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Analysis of miR-124 Variants and Their Expression in Hepatocellular Carcinoma Cell Lines

This study investigates the expression profiles of miR-124-1, miR-124-2, and miR-124-3 across various regions in hepatocellular carcinoma cell lines, specifically JHH-2, Hep3B, and JHH-7. Using BstUI site analysis, we examine the methylation patterns in CpG sites and their regulatory effects on miR-124 expression. Our findings highlight the differential expression of these miRNAs and their potential implications in cancer biology, thus providing insights into the epigenetic regulation of hepatocellular carcinoma.

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Analysis of miR-124 Variants and Their Expression in Hepatocellular Carcinoma Cell Lines

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  1. Supplementary Fig. S2 > miR-124-2 miR-124-1 Cen Tel Cen Tel BstUI site BstUI site CpG site > CpG site Region 1 Region 1 Region 3 Region 2 Region 4 Region 2 C40 C40 (+) (+) JHH-2 JHH-2 Expression Expression Hep 3B Hep 3B (-) (-) JHH-7 JHH-7 miR-124-3 Tel Cen BstUI site > CpG site Region 1 Region 3 Region 2 Region 4 C40 (+) JHH-2 Expression Hep 3B (-) JHH-7

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