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Characterization of DNA Repair Activity Involving 8-oxo-dG and Associated Enzymes

This supplementary figure (S2) illustrates the activity and interaction of various DNA repair enzymes against 8-oxo-dG, dG, and 8-Cl-dG substrates. It includes data on human enzymes like hNEIL1, hAAG, EndoV, hOGG1, and FPG, highlighting their roles in cleaving damaged DNA and their efficiencies under different conditions. This analysis is critical for understanding the mechanisms behind oxidative DNA damage repair and the specific contributions of each enzyme in maintaining genomic integrity.

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Characterization of DNA Repair Activity Involving 8-oxo-dG and Associated Enzymes

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  1. Supplementary Figure S2 (A) (B) (C) 8-oxo-dG dG 8-Cl-dG hNEIL1 - - + + hAAG EndoV hOGG1 hOGG1 hOGG1 - - - - FPG FPG FPG - - + + APE 1 1 4 2 3 2 3 2 3 4 5 6 7 8 9 1 38 38 38 30 10

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