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Infectious Diseases Unit 5 Lesson 2 plan

Infectious Diseases Unit 5 Lesson 2 plan. Do now. What is Innate Immunity?. Do now. What is innate immunity? N on-specific mechanisms of immune defense that do not change. Review of immune structures. Physical Chemical Cellular. Cancer Cell. Neutrophil.

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Infectious Diseases Unit 5 Lesson 2 plan

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  1. Infectious Diseases • Unit 5 Lesson 2 plan

  2. Do now • What is Innate Immunity?

  3. Do now • What is innate immunity? • Non-specific mechanisms of immune defense that do not change.

  4. Review of immune structures • Physical • Chemical • Cellular Cancer Cell Neutrophil A neutrophil ingesting a cell

  5. Physical • Skin • Mucus • Tears

  6. Chemical • Defensins • Complement • Stomach Acid

  7. Cellular • Innate cells: • Macrophages • Dendritic cells • Neutrophils • Adaptive cells: • B cells • T cells

  8. All immune cells are made in bone marrow They all come from a parent cell (stem cell) Innate cells Adaptive cells

  9. Innate cells patrol the body using receptors to identify invaders Neutrophil Macrophage

  10. PAMPs (Pathogen Associated Molecular Patterns) • Innate immune receptors ‘see’ foreign molecules called PAMPs • PAMPs may be: • Bacteria or fungal cell wall parts,like PS • Flagellin(flagellum protein) • Bacterial DNA • Viral RNA Do you think PAMP patterns will be found in host cells?

  11. Innate cells respond to invaders in two ways • Phagocytosis: Eating the invader • Chemotaxis: Recruiting help

  12. Eating the invader:Phagocytosis • http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter2/animation__phagocytosis.html

  13. Eating the invader:Phagocytosis

  14. Recruiting help:Chemotaxis

  15. Innate cells also activate adaptive cells • After digesting the pathogen some innate cells stick its parts (antigens) on their cell membrane: • They are called Antigen Presenting Cells (APCs) • By presenting the antigens like this they can activate T cells.

  16. Wrap up • Physical and chemical barriers are part of the innate immune system on the outside of the body. • Innate cells are in the sterile interior. • Innate cells have receptors that see pathogen associated patterns (PAMPs) not found in the host (non-self vs. self). • After recognizing a PAMP innate cells phagocytose the invader and present its antigens on their surface. • Then they secrete chemokines to call for help from more innate cells. • Innate receptors cannot adapt to mutating PAMPs, so they may also call for help from the adaptive immune system.

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