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The Application of Plasma for SUDs

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  1. The Application of Plasma for SUDs Non-thermal Atmospheric Plasma (NTAP) Electrode MEM-031 Shawn Anderson William Borrell John Mattero Joseph Neal Royston Rodrigues Advisors: Dr. Y. Cho Dr. A. Fridman

  2. Bacteria Basics • Ubiquitous in all habitats on Earth, even nuclear waste • Make up much of the Earth’s biomass • Most are harmless, a few are beneficial, some pathogenic • Classified as prokaryotes – lack a defined nucleus and the majority do not contain membrane bound organelles

  3. Bacteria Morphology • Typically 0.5 – 5.0 micrometers in length • Two main shapes: • “-coccus” – spherical as in Dianococcus Radiodurens • “Baccillus” – rod shaped as in Baccillus Subtilis

  4. Talk about Sterilization

  5. Talk about current sterilization technologies (and why they’re no good)

  6. Talk about Plasma – Greg has good slides!

  7. Define Sterilization

  8. Specifications of the Box

  9. Specs of the Electrode

  10. Plasma Characterization • Talk about plasma characterization • talk about power source characterization (get data from posters)

  11. Power Source Characterization

  12. EXPERIMENTS • What can our box do????

  13. PROTOCOL

  14. DEMO

  15. Production

  16. REPROCESSING SINGLE-USE MEDICAL DEVICES • Single-Use Medical Devices (SUD) • Scalpel handles, forceps, scissors, speculums, etc. • Defined as used, open, or expired • FDA and MDUFMA • Validated sterilization procedures must accompany 510K submissions • Requires similar standards as OEMs

  17. WHY REPROCESS • If 1-2% of all SUDs were reprocessed, savings of $1,000,000,000/yr • Up to 50% savings when reprocessing once • 10 Million tons of waste diverted from landfills each year • Increased reliability

  18. COMPETITIVE ADVANTAGES • Size • Scalable to large container size • Possible conveyor belt mechanism with automated sterilization • Efficacy • Proven to kill D. radiodurans, E. coli • Short duration exposure times • 30sec to 10hrs • Safety • Runs off 110V wall power supply • Non-thermal plasma safe to touch

  19. SENIOR DESIGN BUDGET

  20. Industrial Budget

  21. Dr. Young Cho Dr. Alexander Fridman Dr. Greg Fridman Moogega Cooper Drexel Plasma Institute

  22. REFERENCES – ADD THESE WITHIN THE PRESENTATION (CITE FIGURES) 1 http://www.myendosite.com/cms/files/July_1998_ID478.pdf • http://www.unc.edu/depts/spice/dis/ICHE-1996-Feb-p87.pdf • http://www.devicelink.com/mddi/archive/02/09/003.html • http://books.google.com/books?id=3f-kPJ17_TYC&pg=PA351&lpg=PA351&dq=plasma+sterilization+medical+devices&source=bl&ots=KkCpEv8PFZ&sig=hvTIRX2UtewsEEo0qgKqcfs8ugQ&hl=en&ei=7P2tSfHpCIiSngeElojDBg&sa=X&oi=book_result&resnum=7&ct=result • http://www.swri.org/3pubs/ttoday/Spring96/ttoday2.htm • http://www.gregfridman.com/publications/documents/STAR-RyanRobinson.pdf • Laroussi, Mounir. "Low Temperature Plasma-Based Sterilization: Overview and State-of-the-Art." Plasma Processes and Polymers 2 (2005): 391-400. • Fridman, Gregory, Peter I. Lelkes, and Kenneth Barbee. "Physical and Biological Mechanisms of Plasma Interaction with Living Tissue." Prepublication (2007).