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CPPT 9010: Facility Design & Operation. D.I.T. DT275 Masters in Chemical and Pharmaceutical Process Technology 17 th December 2009 Clement Farrar BA BAI MSc MIEI. Lecture Overview. 1) General Support Utilities 2) Water 3) Clean Steam 4) Waste 5) CIP & SIP 6) Autoclaves 7) Washers

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Cppt 9010 facility design operation
CPPT 9010: Facility Design & Operation

D.I.T. DT275

Masters in Chemical andPharmaceutical Process Technology

17th December 2009

Clement Farrar


Lecture overview
Lecture Overview

1) General Support Utilities

2) Water

3) Clean Steam

4) Waste

5) CIP & SIP

6) Autoclaves

7) Washers

8) Solution Transfer

1 support utilities
1) Support Utilities

  • What are Support Utilities?

  • Why do we need Support Utilities?

Support utilities
Support Utilities

  • Essential Utilities

    • Clean Steam Generators

    • WFI Generators

    • RO Skids

    • Potable Water

    • Process Air

    • CIP Skids

  • Other Utilities

    • Glycol

    • Instrument Air

    • CO2

    • O2

Clean steam cs
Clean Steam (CS)

  • Clean Steam is generated with Clean Steam Generators by the distillation of RO or WFI

  • Clean Steam is used for sanitization

Water for injection wfi
Water For Injection (WFI)

  • Water for Injection (WFI) is a raw material (excipient)

  • Needs to be ‘clean’ - stripped of any inorganics, organics, microorganisms and have low level of endotoxins

  • Suitable to inject intravenously

  • Uses include:

    • Final rinse for CIP’s

    • Clean Steam generation

    • Product formulations

    • Equipment washing


  • Oxygen O2

    • Oxygen is an essential requirement for the growth of cells (in the case of bio-processing)

    • It is sparged through the bioreactor vessels via the oxygen/ carbon dioxide distribution loop

  • Carbon DioxideCO2

    • Carbon Dioxide is used to maintain the desired level of oxygen

    • It is sparged through the reactor vessels via the oxygen/ carbon dioxide distribution

Other utilities
Other Utilities

  • Glycol

    • Glycol is used as the coolant (through vessel jackets)

    • Glycol is stored in a Process Glycol Surge Tank

    • Glycol is distributed throughout the process via the Glycol Distribution Lines

  • Instrument Air

    • Instrument air is high pressure air which is used to operate actuator valves and does not contact process contact surfaces

Hvac heating ventilation air conditioning

Air Handling


Production Room








HVAC (Heating, Ventilation & Air Conditioning)

  • HVAC System

    • HVAC systems are located in the interstitial places between the building floors

    • Its purpose is to maintain the heat, ventilation and air conditioning at the desired level

Process waste treatment
Process Waste Treatment

  • Process Waste must be treated prior to discharging from site

Cleaning steaming
Cleaning & Steaming

  • Before process equipment can be used it must be Cleaned and Steamed (or Autoclaved)

  • Clean in Place (CIP)

    • Method of cleaning the process equipment and associated pipe-work using a variety of cleaning agents such as RO Water, Caustic, Acid and WFI

  • Steam in Place (SIP)

    • Method of sanitizing the process equipment and associated pipe work by steaming at high temperatures (~121°C) until certain criteria are met and all micro-organisms are killed

Water overview
Water Overview

  • Utility Water

  • Clean Water

  • Softened Water System

  • RO (Reverse Osmosis) Water System

  • WFI (Water for Injection)

Utility water plant flow chart
Utility Water Plant Flow Chart



User 1

Utility Water

Storage Tank

Chlorine Analyser




User 2

User 3

Chlorine Analyser

Distribution Pumps

User 4



Storage Tank




User 5

Inlet from Local County Council

Utility water usage
Utility Water Usage

  • Uses of Utility Water

    • As utility water in all buildings (for cooling)

    • Domestic Water Supply to all buildings

    • Supply to the cooling towers

    • Chilled Water

  • Utility water feeds the softened water generation plant

    • For generation of RO & WFI

    • Boiler feed water

  • Why do we need clean water
    Why do we need ‘Clean Water’?

    • Water for Injection (WFI) is a raw material (excipient)

    • Suitable to inject intravenously

    • Needs to be ‘clean’ - stripped of any inorganics, organics, microorganisms and have low endotoxin

    • Specification of WFI defined in various Pharmacopeia’s

    How do we make clean water
    How do we make ‘Clean Water’?

    • Drinking water is supplied to the facility

    • Drinking water undergoes a series of purification steps to turn it into WFI

    • Examples of Purification steps include softening, deionisation, distillation

    Soft water generation
    Soft Water Generation

    • Utility Water supplied to Soft Water plant

    • Soft Water Generation

      • Water is softened by removing hardness ions (Ca2+ and Mg2+) present in drinking water

      • Softener resins replace the hardness ions with sodium ions (Na+)

      • Soft Water plant also removes particulates from water using multi media filters

      • Soft Water is dosed with chlorine to control microbial growth

    Soft water plant sample schematic
    Soft Water Plant - Sample Schematic

    User 1

    User 2

    User 3

    User 4

    To Site Distribution

    User 5

    User 6

    Multi Media #3

    Water Softener #1

    Soft Water Storage Tank

    Bisulfite Addition

    Water Softener #2

    Multi Media #2

    Distribution Pumps

    Water Softener #3

    Multi Media #1

    Utility Water Inlet

    Hypochlorite Addition

    Hardness Analyser

    Reverse osmosis ro generation
    Reverse Osmosis (RO) Generation

    • RO membranes remove dissolved organics and inorganic contaminants from soft water

      • High pressures drive water molecules to pass from higher to lower concentrated solution

    • Opposite to osmosis

    • Achieves good salt reduction (approx 95%)

    • Requires constant removal of waste stream (concentrate) to optimise performance

    • Requires routine sanitisation (heating) and cleaning (chemical) to ensure quality

    Reverse osmosis water generation sample schematic




    0.5 um FILTER









    0.5 um FILTER





    Reverse Osmosis Water Generation - Sample Schematic

    RO Generation Capacity 17 m3/ hr

    Water for injection wfi generation
    Water for Injection (WFI) Generation

    • WFI generated through distillation

      • Requires boiling RO feed water and condensing distillate

      • Phase transfer

      • Separates dissolved and undissolved impurities from the water

    Water for injection wfi generation1
    Water for Injection (WFI) Generation

    • Impurities need to be frequently removed (blowdown) to ensure quality

    • Any microorganisms killed during phase transfer

    • Endotoxins separated during phase transfer

    Storage and distribution systems
    Storage and Distribution Systems

    • Not just generation of ‘Clean Water’ that is important

    • Storage and distribution systems are equally (if not more) important than generation

    • USP and EP WFI biological specifications are very high

      • Bioburden <10 cfu/100ml

      • Endotoxin <0.25 EU/ml

    • Storage and distribution systems are designed to minimise microbial growth

      • High distribution temperatures

      • Pipework surface finish

      • Continuous, turbulent flow

      • Zero dead-leg valves

    Wfi system use maintenance
    WFI System Use/ Maintenance

    • The manner in which the WFI distribution system is used/ maintained is also important

    • WFI is easily contaminated (biologically and chemically) by people

    • Care required with usage to ensure that WFI specifications are met

      • Use of IPA

      • Use of clean autoclaved hoses/ gaskets

      • Flushing prior to use

      • Management of the user points

    Wfi specifications and sampling considerations
    WFI Specifications and Sampling Considerations

    • EP and USP define WFI biological and chemical specifications

    • Extensive sampling is performed daily on WFI systems to ensure water quality

      • Daily biological samples

      • Continuous conductivity and TOC analysers

      • Heavy metals, nitrates and description test performed weekly

    • System performance continually monitored to ensure operating within validated range

    • Investigations required for any out of specifications

    What is clean water used for
    What is ‘Clean Water’ used for?

    • WFI can be the most widely used Raw Material at a Pharma Facility

    • WFI Uses include:

      • Final rinse for CIP’s

      • Clean Steam generation

      • Raw material used for media and buffers make up

      • Product formulations

      • Make up water for product contacting CIP’s

      • Equipment washing

      • Area Cleaning

      • Sinks

    Clean steam overview
    Clean Steam Overview

    • What is Clean Steam?

    • Where is it Used?

    • How is it Made?

    • Pipe Work & Components

    • Standards

    Clean steam what is it
    Clean Steam - What is it ?

    • Pharmaceutical Clean Steam is a pure heat source used in pharmaceutical sanitisations (mostly)

    • Clean Steam is generally any steam system that is qualified

    • Routinely monitored and Quality tested.

      • Have to demonstrate absence of microorganisms in a condensed steam sample

      • Have chemical specifications that must be complied with

      • Regulatory requirement to comply to biological and chemical specifications for these systems

    Clean steam what is it1
    Clean Steam - What is it ?

    • Clean steam is simply steam that contains very little impurities when condensed back to water

    • It is generated and distributed in a way that reduces potential impurities (biological or chemical) from reaching use points

    Clean steam where is it used
    Clean Steam - Where is it used?

    • cGMP Autoclaves (decontamination autoclaves may use Plant Steam)

    • Manufacturing Process (SIP’s) - throughout all manufacturing areas & processes clean steam is used for sanitisation

    • Other uses include:

      • Used in agitator seals in Bioreactors for sterile boundary.

      • Used to supply HVAC humidification (instead of dedicated hum steam generator)

    Clean steam how is it made
    Clean Steam - How is it made?

    These are the 1850Kg/Hr & 2800Kg/hr clean steam generators

    Clean steam pipework components
    Clean steam - Pipework & Components

    • Clean systems generation & distribution systems are made up of 316L s/s electropolished high purity piping components.

    • Condensate build up in clean steam systems is to be avoided – it can affect clean steam dryness quality and if left accumulate on distribution systems can present bioburden issues.

    • ‘Trapping’ – the removal of condensate

    Clean steam trapping
    Clean Steam Trapping

    Example of Steam Trap: balanced pressure type from Spirax Sarco - there are different sizes and different condensate capacities available

    Clean steam pipe work components
    Clean Steam - Pipe-Work & Components

    • Steam separators (to help improve steam dryness).

    Trap Set


    Typical Pressure

    Reduction Set

    Clean Steam


    Clean steam specifications
    Clean Steam Specifications

    • CS Condensate requirements: Clean steam condensate = WFI quality

    • Currently no section dedicated to clean steam so clean steam is required to meet current pharmacopia requirements for WFI

    Construction guidelines best practices e g ispe guidelines
    Construction Guidelines / Best Practices (e.g. ISPE Guidelines)

    • Clean steam systems are sloped to assist with condensate removal usually in the direction of steam flow - is as per WFI sloped pipework 1:100

    • Steam lines should be sized to give a max velocity of 25M/sec - this is again to ensure trapping is not negated

    Construction guidelines best practices e g ispe guidelines1
    Construction Guidelines / Best Practices (e.g. ISPE Guidelines)

    • Clean steam traps - vertically mounted, steam off takes from top of pipes etc

    • The material of gaskets used on ASME BPE clamps and valves on clean steam distributions are an important consideration

    Waste neutralisation overview
    Waste Neutralisation - Overview Guidelines)

    • Consists of Waste Neutralisation Tank and ancillary equipment

    • Its function is to treat the Process Waste prior to discharging to the Local Authority Sewer

    Waste neutralisation functionality
    Waste Neutralisation Functionality Guidelines)

    • Waste Neutralisation Tank - Critical Parameters

      • pH

      • Temperature

      • Availability of Oxygen

      • Flow to Sewer

    Waste neutralisation functionality1
    Waste Neutralisation Functionality Guidelines)

    • pH

      • Waste can have a too high or too low pH

      • pH corrected using H2SO4 for high pH

      • pH corrected using NaOH for low pH

      • pH of the effluent is continually adjusted between 6 - 8

    • Temperature

      • Generally if the temperature rises above 37 Deg C, the cooling supply to the re-circulation line heat exchanger is activated and the effluent is cooled

    Waste neutralisation functionality2
    Waste Neutralisation Functionality Guidelines)

    • Availability of Oxygen

      • It is critical to keep the neutralisation tank oxygenated to avoid the proliferation of Anaerobic bacteria

      • There are generally air blowers attached to an air jet system located at the bottom of the tank

      • Oxygen is monitored in the tank and sustained at a level that will restrict Anaerobic zones where anaerobes may grow

    • Flow to Drain

      • When the discharge limit is reachedthe Sewer Valve can be interlocked to maximise the usage of the capacity of the tank on occasions

    Why waste must be treated
    Why Waste Must be Treated Guidelines)

    • The EPA (Environmental Protection Agency) and Local County Council issue a License called an Integrated Pollution Control (IPC) License to every facility to allow the site to go into operation.

    • Each facility is responsible for continuing to operate within the limits/ requirements outlined in the license.

    • Each facility should have a monitoring program that includes daily, weekly, monthly, quarterly and annual monitoring events.

    • Most importantly each site must restrict the effluent discharged from site on a daily basis to the specified limit!

    Potential ipcl issues
    Potential IPCL Issues Guidelines)

    • Too Much Water Being Generated on Site.

    • Intermittent Elevated Suspended Solids

      • The waste tank is a great home for Bugs as there can be a constant source of food and ambient temperatures there

    • Intermittent Elevated Sulphate Concentrations

      • Dosing Large Volumes of Sulphuric Acid Due to the Alkali Nature of Waste from CIP activities (Caustic Cleans)

    • Breaches of the effluent dischargelimit are defined as pollution events.

    • Consequence of continual license excursions would lead to fines and even a site shutdown

    Waste neutralization plant review
    Waste Neutralization Plant Review Guidelines)

    Waste Neutralisation System


    Operational Issues

    Suspended Solids

    Volumetric Flow

    Mech & Civil Repairs Required






    5 cip cop
    5) CIP/ COP Guidelines)

    Cip cop
    CIP/ COP Guidelines)

    • CIP (Clean In Place)

      • Automated chemical cleaning system

      • Fixed vessels and transfer lines

      • Validated process and procedures

      • Equipment is cleaned by combination of heat, force and chemical exposure

    • COP (Clean Out of Place)

      (Generally for smaller equipment)

      • Portable Vessels

      • Small Components (e.g. Manual Valves, Probes)

      • Miscellaneous Equipment

    Cip cycle
    CIP Cycle Guidelines)

    • Used on Lines & Vessels

    • Lines are generally quick as they are small in comparison with vessels

    • CIP cycles use hot chemical solutions

      • CIP 100 solution (KOH, base or caustic)

      • CIP 220 solution (HCl, Acid)

      • Blow down steps

      • RO & HWFI rinses

    Cip cycle1
    CIP Cycle Guidelines)

    Steps in the Cycle are typically:

    • Step 1: Reverse Osmosis (RO) water rinse

    • Step 2: Blow down

    • Step 3: Caustic solution rinse

    • Step 4: Blow down

    • Step 5: RO rinse

    • Step 6: Blow down

    • Step 7: Acid solution rinse

    • Step 8: Blow down

    • Step 9: Hot Water for Injection (HWFI) rinse

    • Step 10: Blow down

    Question Guidelines)

    • 1) Do we need to CIP a vessel if we are going to transfer the EXACT same solution in it again?

    • 2) Why?

    Gmp expectations
    GMP Expectations Guidelines)

    • 21 CFR 211.67

    • Thorough and reproducible cleaning of equipment and transfer lines is required to prevent malfunction or contamination that would alter the quality and purity of the drug product beyond the established requirements.

    • 21 CFR 211.182

    • Logs of equipment use and cleaning must be maintained.

    • 21 CFR 211.68

    • Automation of the equipment is permitted, but must be subject to routine calibrations, preventative maintenance and inspections.

    Gmp expectations1
    GMP Expectations Guidelines)

    • FDA expects companies to have written procedures (SOP’s) detailing the cleaning process used for equipment.

    • The cleaning cycle will remove product residue as well as cleaning solution from surfaces coming into contact with the product.

    • Companies must validate each cleaning cycle for all pieces of equipment.

    • Companies must have written procedures detailing the validation process of cleaning cycles.

    Advantages of automated cip
    Advantages of Automated CIP Guidelines)

    • Equipment that has been CIP’d receives less wear and tear than items which are cleaned manually.

    • CIP is more efficient than manual cleaning because the vessel has uniform and consistent cleaning.

    • CIP means improved safety for personnel since they have no contact with heated chemical solutions.

    • Labour required for cleaning is reduced.

    • Production may be increased through reduction of down time.

    • Automated technology allows documentation of the cleaning performance which can be monitored

    Cip hazards
    CIP Hazards Guidelines)

    • You have to break into lines and certain vessels to begin a CIP circuit

    • This can lead to incorrect fittings and loose connections (e.g. transfer panels, spool pieces, filter housings).

    • Pressurised air blow (2 bar).

    • Pumps produce (5 bar) when operating

    • Temperatures are in excess of 70oC

    • Heated chemical solutions at high pressure

      (HCl & KOH).

    Cop clean out of place
    COP (Clean Out of Place) Guidelines)

    • Used on small portable vessels and small pieces such as filter housings and spool pieces (COP Bath)

    • Carried out in designated COP station

    • The equipment is cleaned by a combination of heat, force and chemical exposure.

    Cop small vessel
    COP - Small Vessel Guidelines)

    Cop bath
    COP - Bath Guidelines)

    Cop spool piece
    COP - Spool Piece Guidelines)

    Question Guidelines)

    Why not manually wash small parts?

    Cop hazards
    COP - Hazards Guidelines)

    Hazards are the same as for CIP but also include;

    • The need to hook up flexi hoses to the portable vessels to begin circuit

    • This can potentially lead to incorrect fittings and loose connections

    • The vessels and their connections may be hot after cleaning (PPE must be worn)

    • Disconnecting hoses and the emptying of vessels may expose technicians to small volumes of hot cleaning solutions

    • Manual handling of small vessels

    Sip overview
    SIP Overview Guidelines)

    • Automated steaming system

    • Kills microorganisms and spores

    • Releases massive energy when the saturated steam comes into contact with the microorganisms

    Sip operation
    SIP Operation Guidelines)

    • One temperature probe (at the coldest point of the system) controls the sterilisation time - CONTROLLING TEMPERATURE PROBE

    • Other temperature indicators (TI’s) are monitored to ensure uniform sterilisation. These TI’s are ‘trapped’ to ensure adequate condensate removal

    Sip parameters
    SIP Parameters Guidelines)

    • STEAM - must be saturated (in equilibrium with it’s condensate)

      • Saturated steam at a minimum temperature of 121.1ºC

      • Temperatures above 127 oC can affect probe performance and damage gaskets


      • 15 psig

    • TIME

      • Validated for different pieces of equipment using biological indicators ( BI’s )

    Sip key functions
    SIP Key Functions Guidelines)

    • Air Removal

    • Condensate Removal

    Air removal
    Air Removal Guidelines)

    • Steam/ air mix will result in unsaturated steam (saturated steam required to kill microorganisms)

    • Performed by bleeds at high points

    Condensate removal
    Condensate Removal Guidelines)

    • Condensate also creates an unsaturated steam condition

    • Condensate will cause cool spots

    • Removed by low point Traps

    Typical sip cycle
    Typical SIP Cycle Guidelines)

    • Set up system per SOP

    • Assure adequate signage

    • Vent air up to 100o C then close exhaust

    • Heat up system to temp [>121.10C]

    • Hold system at validated temperature

    • Cool down system slowly - maintain positive pressure by adding sterile air to avoid vacuum formation

    • Maintain system closed and sterile under positive pressure

    Sip hazards
    SIP Hazards Guidelines)

    • High temperatures

    • Pressurised steam - can blow off loose connections

    • Unlagged plant in high risk areas

    Sop steam out of place
    SOP (Steam Out of Place) Guidelines)

    • Used on small portable vessels

    • Cycle parameters are the same as for SIP

    • Carried out in designated SOP station

    • Key functions (e.g. air removal) are the same as for SIP

    Sop hazards
    SOP - Hazards Guidelines)

    • High temperatures

    • Pressurised steam - can blow off loose connections

    • Potential for technicians to be exposed to pressurised steam

    Sop recommendations
    SOP Recommendations Guidelines)

    • It’s essential to have someone check the set-up PRIOR to starting a SOP cycle

    • Inform co-workers PRIOR to starting a cycle

    • Watch for leaks at the beginning of the cycle - this is when most leaks start

    6 autoclaves
    6) Autoclaves Guidelines)

    Autoclave Guidelines)

    Autoclave overview
    Autoclave Overview Guidelines)

    • Designed for steam sterilisation of dry goods (e.g. filter housings, hoses, machine parts)

    • Steam sterilisation takes place in autoclave under vacuum for a length of time governed by F0calculations

    • F0calculations give the time taken to achieve desired lethality rate of bacterial spores at a given temperature of steam

    Autoclave process description
    Autoclave Process Description Guidelines)

    • Pre-cycle

    • Pre-conditioning

    • Heating

    • Exposure

    • Post-conditioning

    • Equalisation

    Process description
    Process Description Guidelines)

    • Pre-cycle

      • Leak test

    • Pre-conditioning

      • Vacuum Level & Hold and Pressure Level & Hold or Forced Air Removal

    • Heating

      • Heating Up 1 & 2

      • Filter heat up

    Process description cont
    Process Description Guidelines)Cont.

    • Exposure

      • Sterilisation

    • Post-conditioning

      • Vacuum Level & Hold and Pressure Level & Hold or

      • Slow Exhaust

    • Equalisation

    7 parts washers
    7) (Parts) Washers Guidelines)

    Washer function
    Washer Function Guidelines)

    • Designed to insure adequate cleaning, rinsing and drying of product contact surfaces (e.g. Media/ Buffer/ Filling Line Parts)

    Washer process overview
    Washer Process Overview Guidelines)

    • WFI passes through a heat exchanger before entering the washer sump

    • The heated WFI is pumped through spray jets on loop headers designed to cover all areas of items to be washed

    • Addition of detergent via diaphragm pump

    • Steam coils installed in the sump heat the wash solution.

    • Tank mounted on the side of washer stores hot WFI for once-through final rinse

    • Filtered, heated air is circulated through cabinet during drying cycle

    Washer cycle
    Washer Cycle Guidelines)

    Washer process description
    Washer Process Description Guidelines)

    • Prewash

    • Circulated Detergent Wash

    • 2 x Circulated Rinse

    • Non-circulated WFI Rinse

    • Drying

    Washer process description prewash
    Washer Process Description - Prewash Guidelines)

    • WFI from supply passes through heat exchanger before being pumped into washer sump.

    • Hot WFI is circulated through spray jets on loop headers for specified length of time.

    • Pneumatic ball valve directs water to drain. Cold water is added to drain solution to prevent damage to drain

    Washer process description circulated detergent wash
    Washer Process Description - Circulated Detergent Wash Guidelines)

    • Hot WFI Sump fill

    • Detergent is dispensed to the washer for specified amount of time (Must reach specified conductivity)

    • Circulation

    • Drain

    Washer process description 2 x circulated rinse
    Washer Process Description - 2 x Circulated Rinse Guidelines)

    • As per Prewash

    • Temperature & Time setpoints variable

    Washer process description non circulated wfi rinse
    Washer Process Description - Guidelines)Non-Circulated WFI Rinse

    • Hot WFI Storage tank is filled and maintains its fill during the wash cycle

    • Steam coils maintain heat in tank

    • A separate header system is used for final WFI rinse to provide isolation from the circulated water

    Washer process description drying
    Washer Process Description - Drying Guidelines)

    • Dryer air flows through steam heating coil and HEPA filter before circulation

    • High volume blower circulates the hot air over items to be dried

    Transfer of solutions
    Transfer of Solutions Guidelines)

    Having made up various solutions/ ingredients….. How do you get a solution made in Tank A into Tank B?

    Transfer of solutions1
    Transfer of Solutions Guidelines)

    • Lines

    • Pumps

    • Pressure

    • Transfer panels

      • Let’s look at transfer panels in more depth

    Transfer panels
    Transfer Panels Guidelines)

    • A Transfer panel has a number of ports with hard piping behind them connected to various vessels/ utilities

    • Ports are connected using U-shaped pipes called ‘Jumpers’

    • The jumpers create a closed loop connecting tanks/ utilities which can stretch across different areas

    Jumpers Guidelines)

    Question transfer panel hazards
    Question - Transfer Panel Hazards Guidelines)

    • What types of hazards can you think of that are associated with transfer panels?

    Question transfer panel hazards1
    Question - Transfer Panel Hazards Guidelines)

    When transferring solutions, hazards can include:

    • Incorrect connections

    • Loose jumper connections

    • Breaking/ making connections

    • Pressurised tanks and lines

    • Tank Contents (acids, caustic)

    • Again, the MSDS will contain all info necessary for providing first aid / spillage control