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Potentially relevant CTs identified and screened for retrieval (N=115)

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Potentially relevant CTs identified and screened for retrieval (N=115). RCTs excluded because of: ▪ design ( crossover, combination, retrospective, discontinuation) (N=8) ▪ lack of control group unless duration ≥ 13 weeks (N=26) ▪ other interests (young adults,

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Presentation Transcript
slide1

Potentially relevant CTs identified

and screened for retrieval (N=115)

RCTs excluded because of:

▪ design (crossover, combination,

retrospective, discontinuation) (N=8)

▪ lack of control group unless

duration ≥ 13 weeks (N=26)

▪ other interests (young adults,

pharmaco/vigilance or kinetics (N=9)

▪ Review or meta-analysis (N=6)

▪ Arm with N < 9 (N=2)

Potentially appropriate RCTs to be

Included in the analysis (N=64)

RCTs excluded from analysis because

of data reported elsewhere (N=9)

Long term CTs: duration ≥13 weeks (N=16)

Incomplete reporting of all variables of interest(N=1)

RCTs included in the analysis

Short term CTs: duration ≤12 weeks (N=38)

38 studies

89 arms

3923 patients

slide2

29 studies

65 arms - 3204 patients

Weight gain : compared to placebo

kg

slide3

24 studies

57 arms - 3229 patients

Patients with significant weight gain

slide4

12 studies

32 arms - 1511 patients

slide5

10 studies

27 arms - 1784 patients

mg/dl

slide6

10 studies

27 arms - 1784 patients

mg/dl

slide7

10 studies

27 arms - 1655 patients

mg/dl

slide8

29 studies

64 arms - 3305 patients

somnolence/sedation : compared to placebo

slide9

26 studies

61 arms - 3209 patients