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Welcome to Molecular Biology Through Discovery Tuesday, 15 October 2013 Translation

Welcome to Molecular Biology Through Discovery Tuesday, 15 October 2013 Translation. DNA. Protein. Information. Structure + Function. + Self-assembly. C G A C C A T C G C C T T A G T A C. SQ6: How do you respond to. Alexander Dounce. . . . infinite regress.

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Welcome to Molecular Biology Through Discovery Tuesday, 15 October 2013 Translation

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  1. Welcome toMolecular Biology Through DiscoveryTuesday, 15 October 2013Translation

  2. DNA Protein Information Structure+Function +Self-assembly CGACCATCGCCTTAGTAC

  3. SQ6: How do you respond to. . . AlexanderDounce . . . infinite regress

  4. SQ6: How does protein synthesis avoid infinite regress?

  5. SQ6: How does protein synthesis avoid infinite regress?

  6. SQ6: How does protein synthesis avoid infinite regress? What ideas underlie this scheme?

  7. SQ6: How does protein synthesis avoid infinite regress? AlexanderDounce

  8. SQ5: Evidence that proteins are linear? Sanger and Tuppy (1951)

  9. SQ6: What are the S-S links mentioned by Crick?

  10. Evidence that DNA is linear?

  11. SQ6: How does protein synthesis avoid infinite regress? I don't fully understand the different kinds of genetic code. How would the ribosome know what is overlapping and what is not? Mechanism?

  12. Types of Codes How to keep track of which student wants what questions? 7 students in class Study Question 1:Study Question 2:Study Question 3:Study Question 4: . . . 1456 36 247 34

  13. 4 6 1 2? 4 6 12? Types of Codes How to keep track of which student wants what questions? 19 students in class Study Question 1:Study Question 2:Study Question 3:Study Question 4: . . . 4612

  14. Types of Codes How to keep track of which student wants what questions? 19 students in class Study Question 1:Study Question 2:Study Question 3:Study Question 4: . . . 4,6,12 Variable length code with commas

  15. Types of Codes How to keep track of which student wants what questions? 19 students in class Study Question 1:Study Question 2:Study Question 3:Study Question 4: . . . 040612 Fixed length, 2-digit code

  16. 004106128 201 Types of Codes How to keep track of which student wants what questions? 200 students in class Study Question 1:Study Question 2:Study Question 3:Study Question 4: . . . What kind of code? Fixed length, 3-digit code Degenerate or nondegenerate?

  17. Types of Codes SQ18. The Morse Code uses only two symbols (short, long), yet it can specify each of the 26 letters of the English alphabet. How many symbols do you predict must be used to represent one letter? What kind of code? Length? Degenerate or nondegenerate?

  18. mRNA CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU ACCGUACACUUAGGGCGAU Types of Codes Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . Fixed-length?Variable-length? Degenerate?Non-degenerate? 64 codons 20 amino acids

  19. CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU Types of Codes Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . 64 codons 20 amino acids

  20. Types of CodesOverlapping or not?

  21. Types of CodesOverlapping or not?

  22. Types of CodesOverlapping or not?

  23. Types of CodesOverlapping or not?

  24. Types of CodesOverlapping or not?

  25. Types of CodesOverlapping or not?

  26. Types of CodesOverlapping or not?

  27. Types of CodesOverlapping or not?

  28. Types of CodesOverlapping or not?

  29. Types of CodesOverlapping or not? Possible? SQ23. Consider the codon AGC in an overlapping triplet code. How many possible codons can follow it? If AGC encoded proline, how many amino acids could follow proline?

  30. Types of CodesOverlapping or not? How would the ribosome know what is overlapping and what is not?

  31. GUG AAU UGA Types of Codes SQ22. How to modify the genetic code so that it is not degenerate? How would the ribosome know what is overlapping and what is not? mRNA ACCGUACACUUAGGGCGAU

  32. GUG UGA Types of Codes SQ22. How to modify the genetic code so that it is not degenerate? How would the ribosome know what is overlapping and what is not? mRNA ACCGUACACUUAGGGCGAU Comma-less code

  33. Comma-less Code Can AAA be part of a comma-less code? SQ28. If AGA is a legal codon, then what two codons become illegal?

  34. . . .

  35. Translation Me Take your pick Problem Set 7 #1 Problem Set 7 #5 Problem Set 7 #6

  36. Kaleigh Jonathan Michael Colleen AbdulCailin Sue Kristen Bobby Supriya Tayab Shahroze Mandi Shaun 1. Sample summaries #1 & #2 2. Problem Set 7 #5 (VA ID) 3. Problem Set 7 #6 (overlap) Abdallah Celeste Neda Yordanos Me

  37. Central Dogma: DNA to RNA to Protein Replication DNA Processing /Translocation

  38. SQ22: Interpret T-E-A-T-E-N-D as triplets that are: {overlapping, partially overlapping, non-overlapping} I was wondering what was the distinction between an overlapping and partially overlapping triplet nucleotide codon was

  39. mRNA CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU ACCGUACACUUAGGGCGAU Study Question 11Degeneracy and frequency of amino acids Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . Fixed-length?Variable-length? Degenerate?Non-degenerate? 64 codons 20 amino acids

  40. CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU GUG Study Question 11Degeneracy and frequency of amino acids mRNA Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . ACCGUACACUUAGGGCGAU 64 codons 20 amino acids

  41. CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU GUG Study Question 11Degeneracy and frequency of amino acids mRNA Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . ACCGUAAACUUAGGGCGAU 64 codons 20 amino acids

  42. UUG Study Question 11Degeneracy and frequency of amino acids mRNA CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . ACCGUAAACUUAGGGCGAU 64 codons 20 amino acids

  43. Study Question 11Degeneracy and frequency of amino acids mRNA CodonsAAAAACAAGAAUACAACCACG. . .UUAUUCUUGUUU Amino acidsalaninearginineasparagineaspartatecysteineglutamateglutamineglycinehistidineisoleucineleucine. . . ACCGUAAAUUUAGGGCGAU UUG 64 codons 20 amino acids

  44. SQ22: Interpret T-E-A-T-E-N-D as triplets that are: {overlapping, partially overlapping, non-overlapping} I was wondering what was the distinction between an overlapping and partially overlapping triplet nucleotide codon was

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