Single gene effects on behavior. How do gene products affect behavior? What methods are used to study single-gene effects? Segregation analysis Gene mapping Differences in mRNA between individuals or cell types correlates with behavior Genetic engineering.
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No dominance = additive
aa Aa AA
aa Aa AA
aa Aa AADominance
Rover is dominant: all F1 and 3:1 F2
Ben-Shahar et al. 2002 Science
Note: pleiotropy, i.e. single gene effects two or more traits
Note that 33 of 34 affected individuals have the C allele; indicating
1 recombination event and tight linkage between C and HD genes
Has been used to study where X-linked genes are expressed
during the first cell division
Dark = female
Light = male
D. melanogaster and D. simulans differ in the interpulse interval (IPI) in male courtship song.
The species differences are retained when pero mutant flies are transformed with conspecific
Cross species transformations with per altered male behavior to approximate the other species.
dunce codes an enzyme
which breaks down cAMP
rutabaga has defective
forms cAMP from ATP
This pathway is also involved
in learning and memory in
the sea slug, Aplysia
Cyclic AMP Response Binding protein
or “knock-in” mice
V1a receptor distribution
D2 receptor distribution
Control - other
(blocks dopamine receptors)Viral-mediated transfer of V1aR alters partner preferences in voles
Time experimental male spent huddling with partner (filled) or stranger (open) female
Lim et al. 2004 Nature