1 / 20

Summary

T. Cruzi Meets Wall Modeling Parasite Interaction with their Environment Cailin K. Andruss Virginia Commonwealth University NSF BBSI Program 2005 - 2006. Summary. Project Overview Specific Problems Addressed Cell Movement Vector Reflecting Results Where to go from here?. Project Overview.

reese
Download Presentation

Summary

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. T. Cruzi Meets WallModeling Parasite Interaction with their EnvironmentCailin K. AndrussVirginia Commonwealth UniversityNSF BBSI Program 2005 - 2006

  2. Summary • Project Overview • Specific Problems Addressed • Cell Movement • Vector Reflecting • Results • Where to go from here?

  3. Project Overview • Chagas’ Disease, caused by infection with the Trypanosoma cruzi parasite, is deadly and wide spread. • Very little is known about the parasite that could be used in treatment and prevention. • The Virtual Parasite Project aims to design an in silico laboratory that provides insight into the parasite-host dynamics of the T. cruzi parasite with its host by modeling the biophysical interactions.

  4. Specific Problem • Cells • Representing a cell • Generating a list of cells • Getting Scheme to talk to SimRender • Swimming • Updating position at each timestep • What happens when the parasite hits a wall?

  5. Cell Movement Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (2, 1, 3)

  6. Cell Movement Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (3, 2, 1)

  7. Cell Movement Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (4, 3, -1)

  8. Cell Movement Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (x, y, 0+r)

  9. Cell Movement Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (2.5, 1.5, .5)

  10. Vector Reflecting Distance / Timestep (1, 1, -2) Radius .5 Type T-cruzi Position (2.5, 1.5, .5)

  11. Vector Reflecting Distance / Timestep (?, ?, ?) Radius .5 Type T-cruzi Position (2.5, 1.5, .5)

  12. Vector Reflecting

  13. Vector Reflecting

  14. Vector Reflecting

  15. Vector Reflecting

  16. Vector Reflecting Distance / Timestep (1, 1, 2) Radius .5 Type T-cruzi Position (2.5, 1.5, .5)

  17. Results • Vectors reflected correctly……some of the time. • In the process of troubleshooting, I found a shortcut that appears to work, but still needs more testing. • Passed all the tests that had made the previous method fail. • However, when visualized in Simrender, there were some odd anomalies.

  18. (Run Simrender)

  19. Where to go from here? • The sphere needs to become an ellipsoid • Refine the calculation of the contact point between the parasite and the wall. • Including the real physics. • Basic Newtonian mechanics (gravity, liquid drag, etc.) • Swimming force • van der Waals interactions with host cells. • Charge-charge and mass-mass interactions with other parasites and the walls. • Optimize and benchmark the calculations • Add randomness • Host cell invasion

  20. Acknowledgements • Dr. Tarynn M. Witten • Dr. Wayne Iba • VPP team • BBSI Students and Staff • BCCL team

More Related