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What is the WHO classification for non-Hodgkin lymphoma? 10 Precursor B cell neoplasms

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What is the WHO classification for non-Hodgkin lymphoma? 10 Precursor B cell neoplasms Peripheral B cell neoplasms Percursor T cell neoplasm Peripheral T cell and NK cell neoplasm. What is the difference between leukaemia and lymphoma? 1 …. WHO classification for Hodgkin’s lymphoma.

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Presentation Transcript
slide2
What is the WHO classification for non-Hodgkin lymphoma?
  • 10
  • Precursor B cell neoplasms
  • Peripheral B cell neoplasms
  • Percursor T cell neoplasm
  • Peripheral T cell and NK cell neoplasm
slide4
WHO classification for Hodgkin’s lymphoma.
  • 10
  • Nodular sclerosis
  • Mixed cellularity
  • Lymphocyte rich
  • Lymphocyte depletion
  • Lymphocyte predominance
slide5
What type of Hodgkin’s lymphoma is most commonly associated with HIV and EBV?
  • 15
  • Lymphocyte depletion.
slide6
Clinically features of a patient with NHL.
  • 1
  • Painless, generalised lymphadenopathy.
slide7
You have a patient who has just presented, you think they may have HL, how likely are they to have B symptoms?
  • 20
  • Commonly just present with painless lymphadenopathy.
  • Nodular sclerosis and lymphocyte predominance are usually free of systemic symptoms (usually present stage 1 or 2).
  • Stages III – IV, or mixed cellularity, or lymphocyte depletion are more likely to have B symptoms.
slide8
What proportion of lymphoid neoplasms are from B cells? What are the other cells of origin?
  • 5
  • 80-85%
  • Most of the remainder are T cells, NK cells are quite rare.
slide9
Different types of euthanasia.
  • 1
  • Active voluntary
  • Non-voluntary
  • Involuntary
  • Passive
slide10
Arguments in favour of euthanasia.
  • 1
  • Autonomy.
  • Dignity.
  • Compassion.
  • Difference between active assistance to die and allowing a person to die is morally irrelevant.
  • Already occurring.
  • Palliative care is insufficient.
  • ..
slide11
Arguments against euthanasia.
  • 1
  • Life is sacred.
  • Morale difference between killing and letting someone die.
  • Slippery slope.
  • Procedural safeguards against abuses are impossible to forsee.
  • Adequate palliative care services already exist.
slide12
Describe the process of giving bad news through the use of an acronym.
  • 0
  • Setting
  • Perception
  • Invitations
  • Knowledge
  • Explore and empathise
  • Strategy and summary
slide13
What are we looking for on observation for a haematological examination
  • 10
  • General appearance
    • racial origin,
    • pallor,
    • bruising,
    • jaundice,
    • scratch marks
slide14
What is the pathophysiology of tumorlysis syndrome?
  • 10
  • Lysis of tumor cells.
  • Release of intracellular contents.
  • Renal failure, multiple organ failure, death.
slide15
Clinical manifestations of hypercalcaemia.
  • 15
  • Fatigue, anorexia, constipation, vomiting
  • Vomiting, confusion, thirst and polyuria
  • Coma, arrhythmia
slide16
Aetiology of hypercalcaemia.
  • 15
  • Primary hyperparathyroidism
  • Malignancy
  • Drug therapy
  • Tourniquet artefact
  • Sarcoidosis
slide19
Give me four causes of spleen enlargement.
  • 1
  • Portal hypertension (cardiac failure?)
  • Lymphoma
  • Anaemia
  • Metabolic
slide20
What are the immediate and long term complications of lymphoma treatment?
  • 5
  • Immediate – nausea, vomiting, inflmaation and ulceration of mucus membranes, alopecia, pancytopenia
  • Long term – 2degree malignancies, fertility, thyroid, hepatic or renal function
slide21
What variant of Reed-Sternbery cell occurs in Nodular sclerosis Hodgkin’s lymphoma?
  • 50
  • lacunar
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